Transplantation of olfactory ensheathing
cells on functional recovery and neuropathic pain after spinal cord injury: systematic review and meta-analysis.
Bridging the transected or contused adult rat spinal cord with Schwann cell and olfactory ensheathing
The common transplanted cell types include Schwann cells, olfactory ensheathing
glial cells, neural stem/ progenitor cells (adult and embryonic), and mesenchymal stem cells (14-17).
Baranger et al., "Role of matrix metalloproteinases in migration and neurotrophic properties of nasal olfactory stem and ensheathing
cells," Cell Transplantation, vol.
Todorovic et al., "Low-dose curcumin stimulates proliferation, migration and phagocytic activity of olfactory ensheathing
cells," PLoS One, vol.
Thus, in another study, we also deduced that subsequent to SCI, treatment with olfactory ensheathing
cell- (OEC-) seeded poly(lactic-co-glycolic acid) (PLGA) complex could not only ameliorate the microenvironment but also promote cell differentiation .
Watanabe, "3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing
glia in the mouse brain," The Journal of Neuroscience, vol.
SOX10 knockout mice showed absence of olfactory ensheathing
cells along the olfactory nerve pathway (51).
That is done either by ensheathing
the penis by a rubber condom commonly known as French Leather or by covering the entrance to the uterus by means of a tampon or a cap commonly known as Dutch cap or a diaphragm or by introducing a sperm killing medicine into the vagina before the sexual intercourse.
Implantation of olfactory ensheathing
cells promotes neuroplasticity in murine models of stroke.
Tetzlaff, "Undesired effects of a combinatorial treatment for spinal cord injury-transplantation of olfactory ensheathing
cells and BDNF infusion to the red nucleus," European Journal of Neuroscience, vol.
The use of olfactory ensheathing
cells , boundary cap neural crest stem cells , skin-derived precursors [8, 9], and bone marrow stromal cells [10, 11] has been attempted for this purpose; however, their accessibility and low yield have posed major obstacles to further research for clinical application.