GlaxoSmithKline today announced that the European Commission has granted marketing authorisation for Nucala (mepolizumab) as an add-on treatment for severe refractory
eosinophilic asthma in adult patients.
We recently received approval to begin a Phase 2a study to evaluate the effect of OC459 in patients with severe asthma who have persistent airway eosinophilia, and trials are also continuing in atopic dermatitis and moderate, steroid-free,
eosinophilic asthma.
Histopathologic evaluation of the skin nodules revealed marked hyperplasia of the epidermis with ballooning degeneration of cells and numerous
eosinophilic intracytoplasmic inclusion bodies (Fig 3).
Non-imunoglobulin E (IgE)-mediated conditions include combined IgE and cell-mediated conditions such as atopic dermatitis (AD) and
eosinophilic oesophagitis (EoE), and pure T-cell-mediated conditions such as food protein-induced enterocolitis syndrome (FPIES), allergic proctocolitis and enteropathy syndromes.
However, making a correct diagnosis can be difficult in cases of the
eosinophilic variant, where the tumor is purely composed of oncocytic cells.
There's another condition called
eosinophilic oesophagitis, which is caused by an allergy, but, either way, your problem needs sorting out.
Topical steroid therapy improved some indicators of mucosal integrity in patients with
eosinophilic esophagitis, but proton pump inhibitor therapy did not, two studies showed.
2,3]
Eosinophilic cystitis (EC) is a rare inflammatory disease of the bladder with unknown etiology, characterized by numerous
eosinophilic infiltrations of the bladder.
The development could lead to new treatments for
eosinophilic eophagitis, or EoE.
Subsets include
eosinophilic gastrointestinal disorders (affects esophagus, stomach, or intestines);
eosinophilic granulomatosis with polyangiitis, aka Churg-Strauss Syndrome, (affects lungs, sinuses, heart, and various organ systems); and hypereosinophilic syndrome (affects blood and organs).
ABSTRACT Research on
eosinophilic and basophilic granulocytes in bivalve species has focused primarily on their morphologies and dye affinities.
Of these,
eosinophilic granulomatosis with polyangiitis, formerly known as Churg-Strauss syndrome, is associated with severe eosinophilia.
