Frequent manifestations of amiodarone-related plulmonary toxicity include subacute diffuse interstitial pneumonia, eosinophilic pneumonia
, and pulmonary fibrosis while multiple lung nodules, diffuse alveolar injury, AC edema with/without ARDS, diffuse alveolar hemorrhage, bronchospasm, and pleural effusion are rare manifestations.
Smoking-related lung pathology represents a histologically and clinically diverse spectrum, ranging from the acute presentation of eosinophilic pneumonia
seen in the context of bolus-type exposures (1) to those affiliated with chronic progressive loss of function and malignancy.
Our case was diagnosed to have IIP for the following reasons: (1) her conditions did not suggest known causes of interstitial lung disease such as drug or inhalational exposure or collagen vascular diseases, (3) and (2) transbronchial biopsy and bronchoalveolar fluid analysis did not show pathogenic findings for hypersensitivity pneumonia, sarcoidosis or eosinophilic pneumonia
. Along with progression of IIP, the test for MPO-ANCA was converted to be positive, and subsequently ANCA-associated renal vasculitis, namely MPA, developed.
In particular, sulfasalazine and mesalazine are used in the management of IBD and both can produce pulmonary toxicity that is usually expressed as NSIP, OP, or eosinophilic pneumonia
[10, 47, 48].
The differential diagnosis of cryptogenic organizing pneumonia (BOOP) includes diseases like community-acquired pneumonia, idiopathic interstitial pneumonias, hypersensitivity pneumonitis, chronic eosinophilic pneumonia
, and sarcoidosis [1,4].
Acute eosinophilic pneumonia
(AEP) was first described as a cause of acute respiratory failure in 1989.
There exists very few reported cases of pulmonary complications of e-cigarettes and these are limited to hypersensitivity inhalational injury, pneumonitis, and acute eosinophilic pneumonia
In fact, this biological therapy has demonstrated no cumulative toxicity over a 4-year follow-up (10).To date, only rare cases have been reported that attribute ustekinumab to eosinophilic pneumonia
or organising pneumonia; however, no cases have been linked ustekinumab to HSP (11, 12).
There is another important cause for peripheral blood eosinophilia, which is eosinophilic pneumonia
. The term chronic eosinophilic pneumonia
was coined by Carrington and colleagues in 1968 to explain a situation characterized by the presence of blood eosinophilia and pulmonary eosinophilic infiltration for which no reason was found.
While eosinophilic pneumonia
and hepatitis are relatively common in minocycline-induced adverse reactions, to date, there are only four case reports of minocycline-induced myocarditis, and this condition is usually not associated with thromboembolic complications [12-15].
Acute eosinophilic pneumonia
among US military personnel deployed in or near Iraq.
is similar to organizing pneumonia in pathophysiology, but is mediated instead by an inappropriate increase in the number of eosinophils and macrophages in alveoli.