Canthus (kanthos, [phrase omitted]) is yet another a Greek term for the angle of the eye (angulus oculi or commissura palpebrarum in TA) that is clinically recognizable in terms like epicanthus
To the Editor: Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES; OMIM#110100) is featured by malformation of the eyelid, including ptosis, epicanthus
inversus, telecanthus, and reduction of the horizontal fissure length with a prevalence of 1 in 50,000.,, If not well treated, BPES could result in strabismus and amblyopia. So far, BPES has been divided into two categories: Type I is characterized by ocular symptoms with premature ovarian failure (POF), while POF is absent in Type II.
, palpebral ptosis and strabismus are the major stigmata of disembryogenesis of eyes and eye appendages encountered in patients with TS (26,27).
The 13-year-old could barely open her eyes and couldn't blink after she was born with a condition called Blepharophimosis Ptosis Epicanthus
Inversus Syndrome (BPES).
On physical examination, bilateral ptosis, epicanthus
, bilateral limited outward gaze, depressed nasal bridge, anteverted nostrils, thin upper lip, downturned mouth corners, and micrognathia were observed, the labial sulcus was obscure on the right side and the mouth corner was sliding to the left while crying (Picture 1).
Clinical examination at 21 months of age noted some dysmorphic features such as hypertrichosis, low anterior hairline, hypotelorism, downslanted palpebral fissures, epicanthus
, anomalous teeth implantation, micrognathia, and dysmorphic, rotated, and low-set ears.
External examination revealed a craniofacial dysmorphism including dolichocephaly, hypertelorism, epicanthus
, proptosis, convex nasal ridge, retrognathia, micrognathia, and small and low-set ears with prominent antitragus, underfolded helix, and absence of right earlobe.
Craniofacial abnormalities can manifest with vast variety of anterior segment abnormalities that include eyelid abnormalities such as ptosis and coloboma, ectropion and epicanthus
Abnormal ophthalmic findings are common in children with confirmed FVS syndrome, which include myopia, strabismus, astigmatism, anisometropia, epicanthus
, color vision deficiency and bilateral congenital cataract21.