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Cardiac resynchronization therapy (CRT) decreased morbidity and overall mortality in selected patients with advanced heart failure and cardiac dyssynchrony.[sup][1] Traditional CRT placed a left ventricular (LV) lead on the LV epicardia through a suitable vein.
Epicardial tissue is known to exhibit brown/beige phenotype due to the presence of brown adipocytes, as indicated by higher expression levels of UCP-1 in the epicardia when compared to other fat depots [20, 21].