AS has discovered that modulating epigenetic
factors prolongs the ability of supporting cells (SCs) to replace HCs after damage.
Summary: Lack of funds from the government and high cost of the procedures are likely to hamper the growth of the epigenetic
Summary: Washington [USA], June 8 (ANI): Increase in the severity of sleep-disordered breathing and sleep disruption are associated with epigenetic
age acceleration, recent findings suggest.
The new company is to create innovative medicines to address neurodegenerative diseases by targeting the epigenetic
underpinnings of neurodegeneration.
MELBOURNE, Australia, April 17, 2019 -- An international research collaboration has discovered that two epigenetic
regulators, TAF5L and TAF6L, maintain self-renewal of embryonic stem cells.
Understanding that her grandparents' experiences of horrific trauma and their subsequent silence affected their epigenetic
make-up, Sicherman began to understand why many children of Holocaust survivors have increased levels of stress hormones and are prone to posttraumatic stress disorder.
"In this paper, we have not only identified the epigenetic
factors that contribute to the memory loss, we also found ways to temporarily reverse them in an animal model of AD," said senior author Zhen Yan, PhD, a SUNY Distinguished Professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB.
The hypothesis was that these so-called epigenetic
changes, which alter the activity of DNA but not the DNA sequence itself, might help explain why two people with identical genes differ in this way.
changes, such as stress and adverse life experiences, to our genetic material -- known as deoxyribonucelic acid (DNA) -- may have a greater impact on our intelligence, a new study has found.
ISLAMABAD -- Environmentally-induced epigenetic
changes, such as stress and adverse life experiences, to our genetic material-known as deoxyribonucelic acid (DNA) -- may have a greater impact on our intelligence, a new study has found.
Onconova Therapeutics, a Phase 3 clinical-stage biopharmaceutical company focused on discovering and developing novel products to treat cancer, with a primary focus on Myelodysplastic Syndromes, announced the presentation of new data highlighting the mechanism of action of rigosertib in combination with azacitidine at the American Association for Cancer Research Special Conference on "Targeting DNA Methylation and Chromatin for Cancer Therapy." The epigenetic
events modulated by rigosertib in combination with either agent resulted in global histone post-translational modifications, differential Pol II association with active histone marks, epigenetic
reprogramming of pluripotency genes, and expansion of primitive hematopoietic pluripotent stem cells.
By analysing data from a genome-scale study of DNA methylation in monozygotic and dizygotic twins, researchers identified genomic regions at which the epigenetic
similarity of monozygotic, or identical, twins are substantially greater than can be explained by their genetic identity.