epigenome


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ep·i·ge·nome

 (ĕp′ĭ-jē′nōm)
n.
The set of heritable chemical changes to an organism's genome, such as DNA methylation or histone modification, that modify gene expression but do not change the DNA sequence itself.

ep′i·ge·no′mic (-jə-nō′mĭk) adj.
References in periodicals archive ?
The aim is to build a field-deployable platform technology that quickly reads someone's epigenome and identifies signatures that indicate whether that person has ever-in his or her lifetime-been exposed to materials that could be associated with weapons of mass destruction (WMD).
I cannot resist quoting some of his words directly: our forbears have left us a valuable genomic compass which guides us after landing on the planet of the genes, but they are not responsible for how other great life languages such as the epigenome and the meta-genome shape our bodies, how we sculpt ourselves in our own way, "blow by blow, line by line", through the daily dialogue with our surrounding environment.
In another study on diabetes, Farzana Suliman and Rama Bakhash conducted a pilot study using 21 blood and stool samples from pediatric patients with type 1 diabetes to uncover the microbiome and epigenome profile of this disease in Qatar.
Our justification for examining enrichment among the top 500 arsenic-associated CpGs was that it was difficult to examine genomic enrichments among a limited number of arsenic-associated CpGs at an FDR <0.05, and arsenic likely has numerous biologic effects on the epigenome that might not reach epigenome-wide significance.
In this process, the DNA sequence does not change but experiences and behaviours change the epigenome, the chemical layer on top of the genes.
With growing concerns regarding prevalence of chronic diseases such as cancer, diabetes and other metabolic diseases, organizations such as the National Institute of Health (NIH), National Cancer Institute (NCI) and the International Human Epigenome Consortium (IHEC) have encouraged advanced research in epigenetics field by undertaking new research initiatives such as the Epidemiology and Genomics Research Program.
Rhelixa is a biotechnology startup with strengths in analyzing epigenome information.
Besides altering the genome with technologies like CRISPR, there also seems to be promise in modifying the epigenome. The epigenome determines which genes are active or not.
These patterns of genes expression are governed by the epigenome that acts as mechanism that tells your genes to switch on or off.
Epinomics developed the ATAC-seq technology, an approach to measure and understand the epigenome. Its technology and analytics platform has been adopted by scientific institutions and commercial organisations.
Epinomics was founded by the team that developed the ATAC-seq technology, a ground-breaking approach to measure and understand the epigenome. Its analytics platform has been adopted by scientific institutions and commercial organisations.