In addition, a diagnosis of acute symptomatic seizure should be made in the presence of severe metabolic derangements (Documented within 24 h by specific biochemical or hematologic abnormalities), drug or alcohol intoxication and withdrawal, or exposure to well-defined epileptogenic
This approach can lead to possible complications, such as cerebrospinal fluid leakage, cerebellar bleeding, subdural or epidural hematoma, and the onset of epileptogenic
foci or brain hematomas .
(1,2) Because antipsychotics can lower the epileptogenic
threshold, seizures are a serious potential adverse effect.
In these diseases, the targets could be located based on pathophysiological changes in involved networks, such as left dorsolateral prefrontal cortex (DLPFC) which is synaptically connected to the limbic system involved in mood regulation and epileptogenic
foci which is hyperactivated in epileptic network.
The RNS System is an adjunctive therapy for adults with refractory, focal onset seizures with no more than 2 epileptogenic
(4,5) Seizures are less common than with other types of brain tumors probably because primary CNS lymphoma involves predominantly subcortical white matter rather than epileptogenic
The investigators found 20 patients had abnormalities on EEG, usually in the temporal epileptogenic
Development of effective epileptogenic
therapeutics, many of which face different kinds of bottlenecks (e.g., regulatory hurdles).
The temporal lobe is deemed to be the most epileptogenic
region of the brain.
The intervention aims at removing the entire epileptogenic
zone--a necessary condition in order to achieve postsurgical seizure freedom .
The number of patients with EEG showing frontal lobe epileptogenic
activity was significantly higher in the ADHD group (3 patients, 100%) and ADHD with epilepsy group (7 patients, 77.8%), when compared to the epilepsy group (0 patients).
Liu et al., "Localization of epileptogenic
zone based on graph analysis of stereo-EEG," Epilepsy Research, vol.