Proteins and amino acids along with vitamin B, lipids and glucose aid with the proliferation phase, whilst the maturation phase requires vitamins C and E for epithelisation
(Barchitta et al., 2019; Bishop et al., 2018; Broderick, 2009)
of the dermis fat graft was completed in two months, leaving well-formed fornices with good fitting of the prosthesis (Figures 1 and 2).
The structural and biochemical composition of AM induces epithelisation
by acting as a substrate for epithelial cell growth and also works as an antiangiogenic, antiinflammatory, and antifibrotic agent.
Therefore, one should not prefer lens materials that would decrease the speed of epithelisation
or prolong it.
The significant wound contraction from 3rd day onwards might be due to wound contraction due to myofibroblasts as well as enhanced epithelisation
by stem cell administered locally.
The possible explanation could be in type II diabetic patients; there are related complications of the disease, such as mechanical changes in the conformation of the bony architecture of the foot, peripheral neuropathy, and atherosclerotic peripheral arterial disease; as a result, the patient may have less tissue epithelisation
, consumption of oxygen, nutrient transportation, and cell detoxification resulting in ulceration in the extremities.
Kakudo et al treated five cases of intractable skin ulcer with autologous PRP, among which three ulcers healed completely within 4 weeks and epithelisation
of wound occurred within 6.6 weeks on average.
In the light microscopy examinations of control group, it was observed on day 0 that there were no significant changes in fibroblast proliferation, collagen formation, vascularization, epithelisation
, and inflammatory cell density.
Wound bed granulation and epithelisation
Treatment of chronic ulcer is ultraviolet rays, amnion for epithelisation
, chorion for formation of granulation tissue and skin grafting.
The test group patients had increased growth of granulation tissue along with epithelisation
, which is generally correlated with the development of a granulating wound bed.