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A small molecular region of an antigen that binds to a particular antibody or antigen receptor on a T cell; an antigenic determinant. A single antigen can have multiple epitopes.

[epi- + Greek topos, place, spot.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Medicine) the site on an antigen at which a specific antibody becomes attached
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈɛp ɪˌtoʊp)

a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant .
[1970–75; epi- + -tope < Greek tópos place; compare topo-]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.epitope - the site on the surface of an antigen molecule to which an antibody attaches itself
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
In patients responding to therapy, significant expansion of the infused MultiTAA cells was observed, along with broad-based epitope spreading, with significant expansion of endogenous T cells specific for other tumor specific antigens.
The combination of the two vaccines provided not only broader epitope coverage, but also a greater therapeutic effect than either vaccine alone.
An ESAT-6 peptide pool containing ESAT-6 P1-P8 (Table S1) was used as the control in the epitope screening experiment.
NetMHCII 2.2 uses artificial neuron networks to predict binding of epitope peptides to HLA-DQ alleles in regions of HLA-DQA10101-DQB10501, HLA-DQA10102-DQB10602, HLA-DQA10301-DQB10302, HLA-DQA10401-DQB10402, HLA-DQA10501-DQB10201, and HLA-DQA10501-DQB 10301.
The B-cell binding site located in the G-H loop (around residues 140-160) of FMDV VP1 protein has been identified as a predominant epitope that elicits neutralizing antibodies against this virus in natural hosts and animal models [4, 5].
Herein, we show that IL-7 induces epitope masking of [gamma]c protein in rapid and energy-independent manner.
The 3D structure of the Ag85B T-cell epitope built by the PyMol molecule builder was subjected to molecular docking simulation with MHC I and II molecules by Molsoft ICM-pro 3.5.
Immunohistochemistry as a procedure is affected by preanalytic variables, such as tissue fixation, embedding the tissue in paraffin, and performance of epitope retrieval, as parts of the actual IHC procedure.
The first was based on a capture antibody toward an epitope located in the region of amino acids 14--21 and a detection antibody recognizing an epitope in amino acid region 26--32.