Specifically, the number of up and downregulated genes involved in mitogen activated protein kinase (MAPK) signalling pathway, endocytosis signalling pathway, cytokine-cytokine receptor interaction, JAK-STAT signalling pathway, Toll like receptor pathway, focal adhesion, erythroblastic
leukemia viral oncogene homolog (ErbB) signalling pathway and transforming growth factor beta (TGF-[beta]) signalling pathway were significantly represented the largest group, which may have an important role in response of spleen in two chicken lines to the E.
For example, evaluation of the status of the v-erb-b2 avian erythroblastic
leukemia viral oncogene homolog 2 (ERBB2, formerly HER2/ Neu) status can stratify subsets of breast cancer patients who are likely to respond to trastuzumab.
Doing so would help pinpoint the role of macrophages in erythroblastic
islands in vivo.
leukemia viral oncogene homolog 2 (ERBB2) is amplified in ~2% of NSCLCs, (17,18) and mutated in ~2% of NSCLCs, (18-20) though it is overexpressed in about 20% of cases.
Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic
anaemia of childhood (Cooley's anaemia) in Cyprus.
However, special stains later revealed atypical blasts negative for myeloperoxidase and positive for hemoglobin, consistent with erythroblastic
The homozygous, recessive hereditary erythroblastic
anemia mouse (hea) is characterized by a hypochromic, microcytic anemia that is lethal 5-7 days after birth.
leukemia viral oncogene homologue 2, neuro/glioblastoma derived oncogene homologue (avian)
Other significantly mutated single genes reported in TNBC include: USH2A, myosin IIIA (MYO3A), PTEN, retinoblastoma 1 (RB1), ataxia telangiectasia and Rad3 related (ATR), ubiquitin protein ligase E3 component n-recognin 1 (UBR1), collagen, type VI, alpha 3 (COL6A3), and several well-known oncogenes [v-raf murine sarcoma viral oncogene homolog B (BRAF), neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), v-erb-b2 avian erythroblastic
leukemia viral oncogene homolog 2 (ERBB2), and v-erb-b2 avian erythroblastic
leukemia viral oncogene homolog 3 (ERBB3)] (18,42,58).
and megakaryoblastic series show normal maturation and morphology.