estramustine


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es·tra·mus·tine

 (ĕs′trə-mŭs′tēn′)
n.
A drug, C23H31Cl2NO3, that combines the actions of estrogen and nitrogen mustard in the treatment of prostate cancer.

References in periodicals archive ?
Androgen-deprivation therapy plus docetaxel and estramustine vs.
After surgery, the patient underwent chemotherapy with docetaxel (DTX) and estramustine.
Increase of beta (III)- and beta(lVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance.
2005) Combination of docetaxel, estramustine phosphate, and zoledronic acid in androgen-independent metastatic prostate cancer: efficacy, safety, and clinical benefit assessment.
2] q week SWOG 9916 Docetaxel + Mitoxantrone + 770 estramustine prednisone TROPIC Prednisone + Prednisone + 755 cabazitaxel mitoxantrone COU-AA-301 Prednisone + Prednisolone + 1195 abiraterone acetate placebo AFFIRM Enzalutamide Placebo 1199 ALSYMPCA Alpharadin Placebo 922 ([sup.
An active regimen of weekly paclitaxel and estramustine in metastatic androgen-independent prostate cancer.
Examples: Taxanes, epothilones, vinca alkaloids, and estramustine Corticosteroids: useful for killing or slowing cancer cells, but also used as anti-emetics and/or to prevent hypersensitivity reactions.
There are different activities but generally these drugs stabilise the overall microtubule structure and resist the depolymerization that occurs during mitosis, so the cells remain frozen or arrested at this (M) phase of the cell cycle An example of an antimicrotubule drug is Estramustine.
66-69) Neoadjuvant chemotherapy with estramustine also produces comparable outcome.
Data from two studies presented at the annual meeting of the American Society of Clinical Oncology showed that docetaxel, alone or in combination with estramustine, can add several months to the mean survival time for men with advanced, hormone-refractory prostate cancer.