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tr.v. es·tranged, es·trang·ing, es·trang·es
1. To make hostile, unsympathetic, or indifferent; alienate: The months of bickering estranged her from her family.
2. To remove from an accustomed place or set of associations: art that is estranged from its historical context.

[Middle English estraungen, from Old French estrangier, from Latin extrāneāre, to treat as a stranger, disown, from extrāneus, foreign; see strange.]

es·trange′ment n.
es·trang′er n.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.estranging - making one feel out of place or alienated; "the landscape was estranging"
disorienting - causing loss of physical or intellectual bearings; "making so many turns to the right and then the left was completely disorienting"; "a sharp blow to the head can be disorienting"
References in classic literature ?
"For your own sake," she said, "don't persist in estranging yourself from me.