Long-term safety and efficacy of etanercept
in children with polyarticular-course juvenile rheumatoid arthritis.
Washington, Jan 31 (ANI): Scientists have found that a drug called etanercept
can restore responsiveness to the pain-relieving effects of morphine in rats that have developed morphine tolerance.
Rather, the patients received etanercept
, an anti-inflammatory arthritis medication, and two other drugs that fight rejection, the researchers report in the Feb.
is a fully human, soluble fusion protein created by the linkage of two ligand-binding regions of the p75 TNF-[alpha] receptor and the Fc portion of human IgG1.
She based that conclusion on data from her group's biologics database, which now includes 218 patients who have received infliximab, 122 who have been treated with etanercept
, 57 with anakinra, and 50 with adalimumab.
The National Institute for Clinical Excellence was expected to say etanercept
and infliximab should be given to patients who have not responded to conventional treatments.
Like the two tumor necrosis factor (TNF)-[alpha] inhibitors, etanercept
(Enbrel) and infliximab (Remicade), anakinra is not approved as a first-line therapy but is reserved for patients who have failed to respond to other disease-modifying antirheumatic drugs.
Contract notice: Delivery of biological medicine etanercept
(32 / pn / 2015 / lch).
Ixekizumab met all primary and secondary objectives in two pivotal Phase III studies, demonstrating superiority to etanercept
and placebo after 12 weeks of treatment for moderate-to-severe plaque psoriasis.
Biologics such as TNF inhibitors (adalimumab, etanercept
, infliximab) and ustekinumab are largely prescribed as second-line therapy when none of the aforementioned options provide the desired results.
As discussed, there are currently five FDA-approved TNF-inhibitors for the treatment of RA, including etanercept
, adalimumab, certolizumab, infliximab, and golimumab (Table 1).
1) and would like to share my experience with regard to a patient develops severe exacerbation of verruca vulgaris under treatment with etanercept