The final outcome is an estimation of euploidy
or trisomy for each studied chromosome.
In this case report, our patient had two chromosomally normal embryos suitable for transfer, despite the fact that the euploidy
rate for individual blastocysts produced by a patient in this age group is typically <20%.
Capalbo et al . previously analyzed the outcome of 215 single euploid blastocyst transfer cycles, and reported the implantation potential of embryos with different qualities to be similar to the extent that none of the three blastocyst morphology parameters described by the present study were predictive of embryo euploidy
. Thus, they suggested that all euploid embryos be considered to be equally viable regardless of their morphology.
The authors observed that, for each year increase in female age, euploidy
rate decreased by 2.9 percentage points in both day 3 and blastocysts (95% CI: -3.8% to -2.0%, p < 0.001), and the odds of achieving at least one euploid embryo were decreased as a function of increased female age in both groups (odds ratio (OR) 0.82, 95% CI 0.70-0.94, p = 0.006).
Encouragingly, the efficacy of this technique appears to be conserved in human oocytes as demonstrated in a preclinical study where reconstructed oocytes successfully overcome age associated aneuploidy with a euploidy
rate of 80% .
(a) Correlation between ovarian response and (i) number of euploid embryos; (ii) aneuploidy rate; (iii) euploidy
rate; (iv) cumulated pregnancy outcome.
The transferred embryo was confirmed as euploidy
because the majority of filtered alleles were within 0.75 < CR < 1.25 in all the 22 autosomes and sex chromosomes.
The characteristic of cell line was tested for viability microorganism detection and chromosome euploidy
according to Liu et al (Liu et al.
Numerical chromosomal changes leading to clones with euploidy
or aneuploidy are classified into groups according to chromosome number.
These results suggest that female triploid Yesso scallops can release mature and functional gametes, and aneuploid progeny closest to euploidy
, especially diploidy, survive longer.