The safety of ezetimibe
has been evaluated in >4700 patients in clinical trials.
Led by first author Kristine Pelton, the team tested ezetimibe
, an FDA-approved hypercholesterolemic drug (Zetia; Merck) against finasteride (Proscar, Propecia; Merck), a standard therapy for the treatment of BPH.
Standard of Care could be any treatment physicians considered appropriate in a real-life clinical setting and included lifestyle modifications as well as lipid modifying agents, such as statins, ezetimibe
The topics include protein structure and function, similarities and differences in the discovery and use of biopharmaceuticals and small-molecule chemotherapies, the structure and business of biopharmaceutical companies and managing risks and resources, recombinant human erythropoietin and its analogues, and the discovery of cholesterol absorption inhibitor ezetimibe
The FDA-approved drug ezetimibe
(sold under the trade-name Zetia) is readily available and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection.
All patients were being treated with a statin at optimal dose, and 18 were also treated with ezetimibe
, a selective cholesterol absorption inhibitor (Table 1).
ABSTRACT: Recent experimental papers in the medical literature have reported successes for a combination therapy for hypercholesterolemia, integrating statin therapy to reduce production of cholesterol in the liver, and the use of Ezetimibe
to inhibit cholesterol absorption by the blood.
Primarily addressing issues in the United Kingdom, the author traces the origins of the controversy and continues to the discovery and development of statins and ending with concerns regarding the effectiveness of ezetimibe
and the safety of torcetrapib.
is the first in the new class of cholesterol absorption inhibitors.
The US has ordered an investigation into Inegy, which combines the widely used statin drug simvastatin with a new medication called ezetimibe
The pill combines a widely-used statin called simvastatin, which blocks cholesterol in the liver, with another drug, ezetimibe
is a lipid-lowering agent that inhibits the intestinal absorption of cholesterol and other related phytosterols.