The five royalty interest assets XOMA acquired from Aronora are: Three Bayer collaboration monoclonal antibody programs targeting factor XI/XIa: BAY1213790 in Phase 2 clinical development; BAY1831865 in early clinical development; and Aronora's AB023 in Phase 2 development; and, Two proprietary hematology programs at Phase 1 and preclinical stage: AB002, a thrombin analog, and AB054, a factor XII
mAb, positioned for acute cardiovascular events, medical device associated clots, and/or inflammation.
Other coagulation abnormalities, such as impaired fibrinolytic activity, factor XII
deficiency and reduced activated partial thromboplastin time have also been reported to be associated with RM, but the corresponding epidemiological data are limited (9).
Antibodies to factor XII
and recurrent fetal loss in patients with the anti-antiphospholid syndrome.
Accordingly, factor activity levels were 74% for Factor VIM; 51% for Factor IX, 103% for Factor XII
, and <1% for FXI.
The reagent employed to calculate the PTT activates factor XII
and so measures factors in the intrinsic and common pathways.
Increased risk for oral cancer is associated with coagulation factor XIII but not with factor XII
. Oncol Rep 2007;18:1537-43.
Normal expression of C1INH and normal C4 usually rule out HAE types I and II but cannot rule out HAE type III, which is thought to be a mutation in coagulation factor XII
gene, which results in increased kinin production.
Other coagulation antibody products that Affinity manufactures include: Factor VII, Factor VIII, Factor IX, Factor X, Factor XI, Factor XII
and Factor XIII.
 Estrogen is found to increase gene expression of factor XII
.  Estrogen receptor-[beta] (ER-[beta]) protein is present in glycoprotein IIb + ve megakaryocytes and platelets.
Myocardial infarction with normal coronary arteries and factor XII
Kaolin promotes clotting by activation of factor XII
, which in turn initiates the intrinsic clotting pathway via the activation of factor XI that ends with the formation of a fibrin clot.