Initiated a Phase 2 clinical trial in July 2019 to investigate MS1819-SD in combination with standard porcine enzyme replacement therapy ('PERT') for patients with CF who suffer from EPI but continue to experience clinical symptoms of fat malabsorption
, despite taking the maximum daily dose of PERT.
AzurRx BioPharma announced that it has initiated a Phase 2 clinical trial to investigate MS1819-SD in combination with standard porcine enzyme replacement therapy for patients with cystic fibrosis that suffer from severe exocrine pancreatic insufficiency, but continue to experience clinical symptoms of fat malabsorption
despite taking the maximum daily dose of PERTs.
Mild to moderate vitamin E deficiency because of inadequate consumption of vitamin E-rich foods and intestinal fat malabsorption
is common in growing children, women of reproductive age and elderly South Asian population.
Chronic bacterial infection of airways and sinuses, fat malabsorption
, infertility in men, increase chlorine in sweat, and exocrine pancreatic insufficiency are the clinical findings.
(3) People with fat malabsorption
and bariatric patients are barely consume fat-soluble vitamin D, and also people suffering from kidney related problem lose 25-hydroxy vitamin D, attached to the vitamin D binding protein through urine excretion.
The prevalence of vitamin A and E deficiency was 13% (2/16), most likely due to fat malabsorption
in at least half of the patients.
Those with darker skin, conditions causing fat malabsorption
, and obesity issues have even more difficulties getting the essential amounts of sunshine vitamin due to their bodys inability to support proper Vitamin D synthesis.
However, orlistat does not decrease body weight as effectively as what is expected for the degree of fat malabsorption
. This phenomenon is partly attributed to the compensation of energy loss due to the inhibition of fat absorption with increased energy intake .
In the present series out of 102, in 6 cases it was more than 6 gm, between 6-7 gm in three and more than 7 gm in three cases, so it seems likely that mild fat malabsorption
may occur in cases of amoebiasis.
According to Grossman, other factors that can put someone at risk of low vitamin D levels include inadequate intake of vitamin D-rich foods over time; conditions such as Crohn's disease, celiac disease, or cystic fibrosis which can cause fat malabsorption
in which the digestive tract does not properly absorb vitamin D; and kidney disease, which makes the body unable to convert vitamin D to its active form.
FHBL homozygotes may experience severe fat malabsorption
and show severe clinical and biochemical manifestations similar to those of ABL.
Causes of vitamin D deficiency include obesity, fat malabsorption
syndromes, bariatric surgery, nephrotic syndrome, a wide range of medications (anticonvulsants and anti-HIV/AIDS drugs), chronic granuloma-forming disorders, some lymphomas, and primary hyperthyroidism.