fetal hemoglobin


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.

fetal hemoglobin

n.
The predominant form of hemoglobin in fetuses and newborn infants, present in small amounts in adults but often elevated in adults with certain forms of anemia and other disorders.
References in periodicals archive ?
In severe beta thalassemia, the level of fetal hemoglobin (Hb F) is markedly increased due to the absence of Hb A, and the amount of Hb [A.
Hydroxyurea is a chemotherapeutic agent that increases the production of fetal hemoglobin and decreases SCD-related complications.
This fetal hemoglobin effectively counteracts the effects of the sickle mutation.
The variability in clinical severity of [beta]-thalassemia has been attributed to environmental and genetic factors, including [alpha]-triplication, [alpha]-deletion and Hereditary Persistence of Fetal Hemoglobin (HPFH), HFE variants and some other unknown mutations (1).
KENSINGTON, New South Wales, July 17, 2017 -- By introducing a beneficial natural mutation into blood cells using the gene-editing technique CRISPR, a University of New South Wales-led team of scientists has been able to switch on production of fetal hemoglobin.
Is there a threshold level of fetal hemoglobin that ameliorates morbidity in sickle cell anemia?
Patients without any of these b-globin gene mutations were transfusion dependent and found to have high fetal hemoglobin (HbF).
shortened erythrocyte survival), increased fetal hemoglobin, carbamylated hemoglobin, iron replacement therapy, and transfusion requirements may interfere with Hb [A.
It has been known for some time that individuals with genetic mutations that persistently elevate fetal hemoglobin are resistant to the symptoms of sickle cell disease and beta-thalassemia, genetic forms of severe anemia that are common in many regions of the world.
In HBSS disease fetal hemoglobin (HbF) is a major modulator of polymerization in that the higher the HbF levels, the more benign the clinical and hematologic features of sickle cell anemia [10].
Sickle-cell syndromes also include sickle-cell trait (HbAS) and sickle-cell anemia, associated with the hereditary persistence of fetal hemoglobin (HbS/HPFH) (BRASIL, 2001a).