Ultrasound accelerates the thrombolytic process through separation of the fibrin strands, which increases the number of plasminogen receptor sites accessible to the fibrinolytic agent
Only 3 patients received a fibrinolytic agent
within 1 hour, 34 did so between 1 and 12 hours, and 63 either did not receive a fibrinolytic therapy at all or received it after 12 hours.
The initial rationale for using ST-segment elevation on ECG as a decision point for early reperfusion therapy in patients with suspected acute coronary syndrome (ACS) was the high specificity for identifying patients who had complete occlusion of a coronary artery and who were most likely to benefit from treatment with a fibrinolytic agent
Today, the fibrinolytic agents
are serine proteases which work by converting plasminogen to the natural fibrinolytic agent
One of the main reasons why primary PCI was considered to be a superior strategy by the attending cardiologists at our center was the fact that the available fibrinolytic agent
was streptokinase, which is not fibrin specific and has a lower rate of achieving TIMI III flow,28,29 however it costs approximately $68 per patient.
Improvements have been made in the management of ischemic stroke, including the use of a fibrinolytic agent
known as tissue plasminogen activator (tPA), and the utilization of stroke response teams.
These results were supported by the CLARITY study of almost 3,500 patients, who were within 12 hours of the onset of a STEMI and were slated to undergo thrombolysis; they received clopidogrel or placebo (they also were treated with aspirin, a fibrinolytic agent
, and when indicated, 48 hours of heparin).
Further research is needed to determine the safest fibrinolytic agent
as well as the most effective dose requirements in adults and children in this setting.
It established that a 2-hour, 2-mg dose of the fibrinolytic agent
restored function in 90% of obstructed catheters.
Pathological development of blood clots requires clinical intervention with fibrinolytic agent
such as urokinase, tissue plasminogen activator and streptokinase (1).
not available in the EC, and a nurse had to fetch it from the pharmacy (4.
Patient demographic and clinical characteristics included sociodemographic variables (gender, age); medical history (hypertension, diabetes, dyslipidemia); the admission time of day (day, evening, or night); and admission day of week (weekday or weekend), the presence of chest pain, the location of myocardial infarction, the fibrinolytic agent
used, the percentages of post-fibrinolytic TIMI-3 flow, and post-fibrinolytic CABG.