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n. fibromatosis, producción de fibromas múltiples en la piel o en el útero.
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In our patient, the fibromatosis was superimposed by an oropharyngeal infection, which created a clinical picture resembling a peritonsillar abscess.
The differential diagnosis is fairly broad and includes phlegmon/abscess, nerve sheath tumor, synovial sarcoma, fibrous histiocytoma (benign, malignant and angiomatoid forms), angiosarcoma, and fibromatosis.
It shares some overlapping features with other infiltrate tumors, such as desmoid-type fibromatosis, neurofibroma, and low-grade fibromyxoid sarcoma.
These disorders include neurofibromatosis type 1 (NF1, OMIM 162200), Legius syndrome (NFLS, OMIM 611431), Noonan syndrome (NS, OMIM 163950), Noonan syndrome with multiple lentigines (also called LEOPARD syndrome, LS, OMIM 151100), Costello syndrome (CS, OMIM 218040), cardiofaciocutaneous syndrome (CFCS, OMIM 115100), Noonan-like syndromes, hereditary gingival fibromatosis (HGF, OMIM 135300), and capillary malformation-arteriovenous malformation (CMAVM, OMIM 608354).
Desmoid-type fibromatosis, also known as aggressive fibromatosis or desmoid tumor, is a rare neoplasm of deep soft tissues that is histologically characterized by an infiltrative, low-grade fibroblastic proliferation and clinically characterized by a tendency for local recurrence but no metastatic potential.
This tumor's differential diagnoses include adenomyoepithelioma, phyllodes tumor, adenoleiomyoma, fibroadenoma with prominent smooth muscle, fibromatosis, benign spindle cell tumor of the breast, fibrous histiocytoma, myoid hamartoma, myoepithelioma, fibromato-sis-like low-grade metaplastic carcinoma and leiomyosarcoma of the breast (9).
These rare breast lesions are fibromatosis, idiopathic granulomatous mastitis, tubular adenoma, diabetic mastopathy, invasive micropapillary carcinoma, osteoclastic giant cell breast carcinoma, malignant phyllodes tumor, carcinoma arising in fibroadenoma, metastasis, and metaplastic carcinoma.
Although it is mainly diagnosed by histological examination of hematoxylin and eosin (H&E)-stained tissue sections, microscopic diagnosis may sometimes be difficult because of the fact that spindle cell proliferation shares many similarities with schwannoma, neurofibroma, fibromatosis, and myofibroma.
The differential diagnosis also includes fibromatosis and cellular schwannoma, but the uniform and highly cellular spindle cell proliferation, the patchy or spotty staining for S100 protein, with the positive staining with SMA helps distinguish LGSSNMF from those lesions.
A diagnosis of nodular fasciitis, proliferating fasciitis, and fibromatosis was ruled out due to dense inflammation, lack of a storiform pattern, and cellularity.
It is also known as subcutaneous pseudosarcomatous fibromatosis, infiltrative fasciitis, or proliferative fasciitis.