Isolation of infected people is currently the centerpiece of filovirus
Jaax led the discovery and eventual containment of the filovirus
, which at the time had a fatality rate of up to 90 per cent.
We conducted a widespread serologic survey for EBOV-specific antibodies in 5 countries in central Africa, including known filovirus-endemic regions (the Democratic Republic of the Congo [DRC], the Republic of the Congo, and Uganda), as well as areas without previously reported filovirus
infections (Ghana and Cameroon).
Ebola is an infectious and frequently fatal disease marked by fever and severe internal bleeding, spread through contact with infected body fluids by a filovirus
Marburg virus is in the same filovirus
family as Ebola.
Howell et al., "Macaque monoclonal antibodies targeting novel conserved epitopes within filovirus
glycoprotein," Journal of Virology, vol.
Ebola virus (EBOV) is a filovirus
that belongs to the Filoviridae family and it causes a severe hemorrhagic disease in human and nonhuman primates.
In addition, in some infections they participate as reservoirs or hosts of coronaviruses that cause severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), Nipah virus paramyxovirus, Hendravirus and filovirus
Under the second USD2.9m four year NIH grant, Dr Lai will develop a broadly neutralizing antibody therapy for Ebola and extend that strategy to Marburg virus, a deadly filovirus
that is distantly related to Ebola.
Against this background seven diseases prioritized for urgent action are Crimean-Congo haemorrhagic fever, Filovirus
diseases (Ebola virus disease and Marburg), highly pathogenic emerging Coronaviruses relevant to humans (MERS Co-V and SARS), Lassa fever, Nipah, Rift Valley Fever, and a "new disease."The seventh disease, denoted as "a new disease" thus refers to any hitherto unknown disease that may emerge and require urgent action to contain or prevent epidemics.
Tambien trasmitidos por mosquitos son los Alfavirus chikungunya y EEV El virus del Ebola pertenece a la familia de los Filovirus
y se transmite entre humanos por contacto con sangre y otras secreciones contaminadas.
La enfermedad por el virus del Ebola (EVE) es una enfermedad contagiosa muy grave causante de brotes con fiebre hemorragica aguda y de gran mortalidad en humanos y en primates no humanos (NHP, del ingles Non Human Primates), producida por un filovirus
con ARN monocatenario de polaridad negativa, morfologia filamentosa y pleomorfica y simetria helicoidal (1), cuyo genoma viral codifica proteinas estructurales que permiten la gemacion del virus e inhabilitan la respuesta inmune del huesped (VP24, VP30, VP35 Y VP40) (2) y proteinas no estructurales que participan en la inmunoevasion del virus (nucleoproteinas y glucoproteinas) (3).