antipsychotic

(redirected from first-generation antipsychotic)
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an·ti·psy·chot·ic

 (ăn′tē-sī-kŏt′ĭk, ăn′tī-)
adj.
Counteracting or diminishing the symptoms of psychotic disorders, such as schizophrenia.
n.
An antipsychotic drug.

antipsychotic

(ˌæntɪsaɪˈkɒtɪk)
adj
(Psychiatry) preventing or treating psychosis
n
(Pharmacology) any antipsychotic drug, such as chlorpromazine: used to treat such conditions as schizophrenia

an•ti•psy•chot•ic

(ˌæn ti saɪˈkɒt ɪk, ˌæn taɪ-)

adj.
1. of or pertaining to any of various drugs used in the treatment of psychosis, esp. schizophrenia, and severe states of mania, depression, or paranoia.
n.
2. Also called neuroleptic. an antipsychotic drug.
[1950–55]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antipsychotic - tranquilizer used to treat psychotic conditions when a calming effect is desiredantipsychotic - tranquilizer used to treat psychotic conditions when a calming effect is desired
chlorpromazine, Thorazine - a drug (trade name Thorazine) derived from phenothiazine that has antipsychotic effects and is used as a sedative and tranquilizer
clozapine, Clozaril - an antipsychotic drug (trade name Clozaril) used as a sedative and for treatment-resistant schizophrenia; know to have few side effects
diphenylbutyl piperidine - a group of antipsychotic drugs used mainly in the treatment of schizophrenia
fluphenazine - tranquilizer used to treat psychotic disorders
Haldol, haloperidol - tranquilizer (trade name Haldol) used to treat some psychotic disorders and Tourette's syndrome
loxapine, Loxitane - a tranquilizer (trade name Loxitane) used to treat schizophrenia
Moban, molindone - antipsychotic drug (trade name Moban) used in the treatment of schizophrenia
prochlorperazine - antipsychotic and antiemetic drug used to treat schizophrenia and to combat nausea and vomiting
Mellaril, thioridazine - a tranquilizer (trade name Mellaril) used to treat schizophrenia and other psychotic disorders
Navane, thiothixene - a tranquilizer (trade name Navane) used to treat schizophrenia
antianxiety agent, ataractic, ataractic agent, ataractic drug, tranquilizer, tranquilliser, tranquillizer - a drug used to reduce stress or tension without reducing mental clarity
Eskalith, Lithane, lithium carbonate, Lithonate - a white powder (LiCO3) used in manufacturing glass and ceramics and as a drug; the drug (trade names Lithane or Lithonate or Eskalith) is used to treat some forms of depression and manic episodes of manic-depressive disorder
Translations

antipsychotic

adj & n antipsicótico
References in periodicals archive ?
Typically, high-potency first-generation antipsychotics such as trifluoperazine and haloperidol are frequently associated with NMS as compared to the second-generation antipsychotics [1, 2].
Efficacy and safety of individual second-generation vs first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis.
Reasons for switching from first-generation antipsychotic to second-generation antipsychotic
Major finding: Use of a first-generation antipsychotic agent was independently associated with a 3.76-fold increased risk of sudden cardiac death.
All the patients were prescribed antipsychotics; 60 (85.7%) patients had a trial on a first-generation antipsychotic, and only 10 (14.5%) were initiated on a second-generation antipsychotic de novo.
The study describes differences in patient characteristics and antipsychotic use patterns between those who received the two first-generation antipsychotic depot formulations and those who received oral formulations.
A link between schizophrenia and diabetes was postulated in the 1920s, (12) and a temporal association between first-generation antipsychotic drug treatment and hyperglycemia was first reported in the 1950s.
(6) Previously, in small placebocontrolled trials, the first-generation antipsychotic (FGA) pimozide was considered first-line treatment for this disease.
The CATIE Trial examined the effectiveness of a number of antipsychotics, comparing four second-generation antipsychotics (olanzapine, risperidone, quetiapine and ziprasidone) with perphenazine, a first-generation antipsychotic. (51) The most significant and unintended finding of this study (and a finding that has subsequently received a great deal of attention) was that 74% of subjects discontinued their treatment before the end of the study.
The investigators randomized patients to treatment with olanzapine, quetiapine, amisulpride, ziprasidone, or to the first-generation antipsychotic haloperidol.
First-generation antipsychotic drugs, as well as certain second-generation agents such as amisulpride and risperidone, are known inducers of hyperprolactinemia (Phan macotherapy 2009;29:64-73).
Whereas first-generation antipsychotic agents generally targeted dopamine, second-generation agents, or atypical antipsychotics, target specific receptor subtypes in the brain.