flagellin


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fla·gel·lin

 (flə-jĕl′ĭn)
n.
Any of a group of proteins that are the structural components of bacterial flagella.

flagellin

(fləˈdʒɛlɪn)
n
(Microbiology) the structural protein of bacterial flagella
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2019), demonstrating that the bacterial flagellin protein, FliC, strongly activates immunostimulatory NF-B signalling, via the TLR5 receptor.
chauvoei are sialidase (HEUERMANN et al., 1991; USEH et al., 2006b; USEH et al., 2003; VILEI et al., 2011), Clostridium chauvoei toxin A (CctA) (FREY et al., 2012), and flagellin (KOJIMA et al., 2000; TAMURA et al., 1995; TANAKA et al., 1987).
fliC encodes the filament portion of the bacterial flagella, flagellin. Flagellin shows substantial antigenic diversity across Salmonella that has been exploited for Salmonella serotyping.
WRKY41, for example was implicated to be overexpressed in Arabidopsis thaliana upon recognising flagellin to enhance the resistance against Pseudomonas syringae which suggest the involvement of WRKY41 in ETI22.
For elucidating effect of quorum sensing (QS) systems I and II (QS-1 and QS-II) on Escherichia coli flagellin expression, E.
Properties of representative chemically identified adjuvants Category Adjuvant Receptor Adaptor Lipid MPL TLR4 MyD88/TICAM-1 Lipopeptide TLR2 (+TLR1 or TLR6) MyD88 Oil, squalane Undefined Undefined Protein Flagellin TLR5 MyD88 Cholera toxin B GM1 receptor G proteins Versican TLR2 MyD88 Nucleic acid Virus dsRNA TLR3, MDA5 TICAM-1 /MAVS Poly I:C TLR3, MDA5 TICAM-1 /MAVS CpG DNA TLR9 MyD88 STING ligand cGAS etc.
While LPSs are specifically recognized by TLR4, the other PAMPs such as flagellin, lipoteichoic acid, peptidoglycan, nucleic acid variants (dsRNA), or unmethylated CpG motifs are recognized by other receptors, such as TLR2, TLR3, TLR5, and TLR9 [79].
Antibodies versus self-cells and tissues had also been described, including: anti-goblet cell antibodies (GAB), characteristic for UC, and versus antigens of exocrine pancreas (PAB), more likely to be found in CD, catepsin G-reacting or flagellin CBir1-reacting (anti-CBir1 flagellin) [10].
Silica crystals (tlrl-sio), nigericin (tlrl-nig), ultrapure flagellin from Salmonella typhimurium (tlrl-epstfla), poly(deoxyadenylic-deoxythymidylic) acid (poly dA:dT, tlrl-patn), monosodium urate (MSU) crystal (tlrl-msu), and carbobenzoxy-valyl-alanyl-aspartyl- [O-methyl] -fluoromethylketone (zVAD-FMK, tlrl-vad) were purchased from InvivoGen (San Diego, CA, USA).
On the other hand, the activation of TLR5 by the flagellin of Salmonella Typhimurium fused with peptide P10 of the gp43 protein of Paracoccidioides brasiliensis eliminated the development of metastases in the melanoma murine model [83], and the use of a TLR5 agonist displayed antitumor effects in a murine lymphoma model while also promoting the activation of [CD8.sup.+] lymphocytes and NK cells [84].
Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells.