Transfers electrons from adrenodoxin reductase to CYP11A1, which catalyzes cholesterol side-chain cleavage FDXR Electron transport flavoprotein
for mitochondrial P450s.
5) Human genes: TBP, TATA box binding protein; UBC, ubiquitin C; SDHA, succinate dehydrogenase complex, subunit A, flavoprotein
(Fp); RLP13, receptor like protein 13; YHWAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; HMBS, hydroxymethylbilane synthase; B2M, fi-2 microglobin; hypoxanthine phosphoribosyltransferase 1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; RPS18, ribosomal protein S18; ACTB, actin, beta; GSS, glutathione synthetase (hGus); 36B4, acidic ribosomal phosphoprotein P0.
Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein
inhibitors diphenylene iodonium and quinacrine.
The proteins belonging to this group are ferredoxins, which represent the iron-sulphur cluster that performs the intermediate step in the electron transfer chain, transferring electrons from the flavoprotein
to the terminal dioxygenase (Bertini et al.
The present volume considers such topics as flavoenzymes involved in non-redox reactions, mechanisms of bacterial luciferase and related flavin reductases, choline oxidase and related systems, toward understanding the mechanism of oxygen activation by flavoprotein
oxidases, glutamate synthase, and flavoprotein
Thioredoxin reductase (TrxR) is a selenoenzyme and flavoprotein
that cacalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of thioredoxin (Trx) and other oxidized dithiols (Stadtman 2000).
In many migratory animals, the light-sensitive chemical reactions involving the flavoprotein
cryptochrome (CRY) are thought to play an important role in the ability to sense the Earth's magnetic field.
A promising candidate radical pair comprises the reduced flavin cofactor (FAD) and an oxidized tryptophan residue in a cryptochrome flavoprotein
(Solov'yov et al.
Other potential orbital antigens include thyroglobulin and cholinesterase epitopes, the flavoprotein
subunit of the mitochondrial succinate dehydrogenase, a 55 kDa protein (G2s), calsequestrin and others (8-11).
SDH catalyzes the oxidation of succinate to fumarate by reducing the flavine adenine dinucleotide (FAD) on its flavoprotein
Complex V = ATP synthase In addition to these complexes, two other electron tranport complexes, DHO-QO (dibydro orotate dehydrogenase CoQ oxidoreductase) and ETF-QO (electron transport flavoprotein
coQ oxidoreductase), play essential roles in energy production.
The cytochromes P-450 result mainly in detoxication, while the cytochromes P-448, flavoprotein
mono-oxygenase, and non-enzymatic free radical hydroxylations are responsible for oxidative activation.