Commonly prescribed ICSs for asthma are beclomethasone dipropionate (QVAR[R]), triamcinolone acetonide (Azmacort[R]), budesonide (Pulmicort[R]), flunisolide
(AeroBid[R]), mometasone furoate (Asmanex Twisthaler[R]), fluticasone (Flovent[R]), and ciclesonide (Alvesco[R]).
Efficient delivery to the lungs of flunisolide
aerosol from a new portable hand-held multidose nebulizer.
The search strategy used for PubMed was "inhaled corticosteroids" OR "ICS" OR "budesonide" OR "fluticasone" OR "flunisolide
" OR "beclomethasone" OR "beclometasone" OR "triamcinolone" AND "COPD" OR "chronic obstructive pulmonary disease" OR "chronic obstructive lung disease" OR "COAD" OR "chronic obstructive airway disease" OR "pulmonary disease, chronic obstructive" OR "airflow obstruction, chronic" OR "chronic airflow obstruction" AND "mortality" OR "death" OR "myocardial" OR "cardiovascular" AND "clinical trial," based on previously published meta-analyses [18, 19].
Group A cases were given oral antihistamine (Cetrizine HCl), intransal corticosteroids (flunisolide
) and commonly used lipid based ointment (petroleum jelly) for intranasal application.
Among several commercially available steroid nasal sprays (Beclomethasone dipropionate, budesonide, flunisolide
, fluticasone propionate, MF and triamcinolone acetonide), we chose to test MF for 4 reasons namely, (1) The drug had been reported previously not to cause any adverse tissue changes in the nasal mucosa of patients treated for long periods, (2) It has no effects on growth in children, (3) It has no effects on the hypothalamic-pituitary-adrenal axis (11) and (4) The systemic availability of the drug after topical administration is lower than that of other steroids.
The global inhalation and nasal spray generic drugs market report estimates the market size (Revenue USD million - 2013 to 2020) for key market segments based on the indication type (allergic rhinitis, asthma, COPD, etc.), therapeutic drug classes (antihistamines, bronchodilators - albuterol, epinephrine; combination drugs - Azelastine (benzalkonium chloride), Formoterol (budesonide), Salmeterol (fluticasone); Corticosteroids - beclomethasone, budesonide, flunisolide
, fluticasone; decongestant sprays - phenylephrine and oxymetazoline hydrochlorides), and forecasts growth trends (CAGR% - 2016 to 2020).
Worldwide, seven ICS drugs are currently available: beclomethasone, budesonide, ciclesonide, flunisolide
, fluticasone, mometasone and triamcinolone.
The participating children used beclomethasone, budesonide, ciclesonide, flunisolide
, fluticasone, or mometasone, delivered by any type of inhalation device, and were followed for 3 months to 6 years.
HFA, 80 mcg) is approved by the US Food and Drug Administration (FDA) for the treatment of asthma in adult and paediatric patients 6 years of age and older.
Comparison of high-dose inhaled flunisolide
to systemic corticosteroids in severe adult asthma.
Ciprandi and coworkers in  found that the use of intranasal flunisolide
was associated with a significant reduction of adenoid hypertrophy in 72.6 % of the children.