A prospective study of paraoxonase gene Q/R192 polymorphism and severity, progression and regression of coronary atherosclerosis, plasma lipid levels, clinical events and response to fluvastatin
MEET THE STATINS EXAMPLES DOSAGE LDL (in milligrams) REDUCED High-Intensity Atorvastatin 40-80 mg (Lipitor[R]) 50% or Rosuvastatin 20-40 mg more (Crestor[R]) Moderate-Intensity Atorvastatin 10-20 mg Rosuvastatin 5-10 mg Simvastatin 20-40 mg (Zocor[R]) Pravastatin 40-80 mg (Pravachol[R]) Lovastatin 40-80 mg 30%-49% (Altoprev[R], Mevacor[R]) Pitavastatin 1-4 mg (Levalo[R]) Fluvastatin
40 mg (Lescol[R]) (twice daily) Fluvastatin
XL 80 mg (Lescol XL[R]) Low-Intensity Simvastatin 10 mg Pravastatin 10-20 mg Less Lovastatin 20 mg than 30% Fluvastatin
20-40 mg Source: 2018 ACC/AHA Guideline on the Management of Blood Cholesterol, Circulation, Nov.
atorvastatin, simvastatin, fluvastatin
, lovastatin) and 1,780 used water-soluble statins (e.g.
Statins are li pid-lowering drugs by c ompeti ti vely inhibiting 3-hydroxy-3-methyl-glutar yl-coenz yme A reductase enzyme (HMGCR) and thus limiting cholesterol biosynthesis.1 Statins are administered daily as standard therapy for primary and s eco ndar y prevention of coronary heart disease (CHD), stroke and peripheral ar terial disease (PAD).2 Commonly used statins are rosuvastatin, atorvastatin, fluvastatin
, lovas tatin, simvastatin, pravastatin and pitavastatin.
Effect of whey protein against fluvastatin
and carbon tetrachloride-induced hepatotoxicity in rats.
Duration of statin use and type of statin (simvastatin, atorvastatin, fluvastatin
, pravastatin, rosuvastatin) also varied.
In the event of recurrent symptoms after same-statin rechallenge, it's reasonable to switch to extended-release fluvastatin
at 80 mg/day or low-dose rosuvastatin daily.
(Grapefruit is unlikely to boost the effects of fluvastatin
, pravastatin, pitavastatin, or rosuvastatin, which are not metabolized by CYP3A4.)
Initially, the agreements cover one product from each partner, Diclofenac ER and Fluvastatin
(30) to determine the mean percent change from baseline for lovastatin (10, 20, 40, and 80 mg), pravastatin (10, 20, and 40 mg), simvastatin (5, 10, 20, 40, and 80 mg), atorvastatin (10, 20, 40, and 80 mg), fluvastatin
(20 and 40 mg), rosuvastatin (5, 10, 20, and 40 mg), and ezetimibe (10 mg; all daily doses).
Baehner et al., "Fluvastatin
reduces proliferation and increases apoptosis in women with high grade breast cancer," Breast Cancer Research and Treatment, vol.