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Related to fragmented red cell: red cell fragmentation syndrome


A red blood cell having an abnormal shape as a result of fragmentation that occurs as the cell flows through damaged small vessels.

[Greek skhistos, split; see schist + -cyte.]
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certain conditions like the presence of fragmented red cell or red cell agglutination that could not have been identified earlier without blood film examination can now be presumably detected on the red cell histogram.
Spiculated forms includes fragmented red cells, burr cells, acanthocytes, tear drop red cells and sickle cell.
The diagnosis of thrombotic thrombocytopenic purpura was confirmed after exclusion of many of the aetiological factors of postoperative digital ischaemia, a positive haemolytic screen and blood film examination which showed schistocytes and fragmented red cells.
Thrombotic microangiopathy (TMA) refers to conditions that cause microvascular thrombosis and result in microangiopathic haemolytic anaemia with presence of fragmented red cells on peripheral blood, thrombocytopenia and end organ damage.