Bu konuda yapilan calismalarda at kestanesi ozunde yer alan aescinin suda cozunurluk ve erime noktasina gore birbirinden ayirt edilen alfa ve beta olmak uzere 2 form triterpene saponin karisimindan olustugu; bunun disindaki bilesenlerin ise bioflavonoidler (quercetinve kaempferol),proanthocyanidin A2 (bir antioksidan) ve coumarinler (fraxin
ve aesculin) oldugu gosterilmistir.
In addition, the coumarin glycoside fraxin displayed free-radical scavenging effect and cell protective effect against hydrogen peroxide-mediated oxidative stress [12, 13].
Ham, "Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress," Experimental & Molecular Medicine, vol.
Some of the coumarins, such as aesculetin, aesculin, and fraxin
, also possess antioxidant activity.
Esculetin, esculin, fraxin
, and fraxetin are some of the pharmacologically active components isolated from different species of Fraxinus plant (Figure 2).
2013), the occurrence of cumarins content in Glucevia[R], including fraxin
, fraxetin, esculin, esculetin, cichoriin, scopolin and fraxidin glucoside was quantified.
Cyclo AMP phosphodiesterase is inhibited and an anti-oxidative (radical trapping action) effect was proven for scopoletine, isofraxin and fraxin
For example salicin is found in Salix spp, Populus spp, Viola spp, and Viburnum spp; fraxin
is found in Fraxinus spp; and both spiraein and salicylaldehyde are found in Filipendula spp.
The main active principles of the anti-exudative effect and improvement of venous tone are hydroxycoumarins (aesculin and fraxin
), triterpene saponins in the petioles and leaf veins, flavonoids and a rich supply of tannins.
S2 has a high content of rutin and S3 a high content of fraxin
. Each of the single extracts modulated a different number of genes based on the microarray assessment: S1 modulated 51 genes, S2 24 genes and S3 31 genes.