Also found in: Medical.
A method of specimen preparation for electron microscopy in which a replica is made from a sample that has been rapidly frozen and then fractured along natural planes of weakness to reveal its internal structure.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.