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A salt or ester of fumaric acid.


(Biochemistry) biochem a salt of fumaric acid produced during the urea cycle


(ˈfyu məˌreɪt)

the salt of fumaric acid, a key chemical intermediate in the Krebs cycle.
References in periodicals archive ?
Lactic acidosis and hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues including lamivudine and tenofovir disoproxil fumarate.
The randomised, double-blind, parallel-group, 24-week, chronic-dosing, multi-centre trial assessed the efficacy and safety of PT010, comparing it to Bevespi Aerosphere (glycopyrronium/formoterol fumarate), Symbicort Turbuhaler (budesonide/formoterol fumarate), and PT009 (budesonide/formoterol fumarate, characterised to qualify as a relevant competitor in clinical trials for PT010).
These studies reported similar outcomes to the randomized clinical trials: significant reductions in the extent and severity of psoriasis with fumarate treatment, and frequent adverse effects, predominantly GI problems, flushing, and laboratory abnormalities.
The combination of dolutegravir plus fixed-dose tenofovir disoproxil fumarate and emtricitabine is administered as 2 pills per day.
The Food and Drug Administration has approved glycopyrrolate and formoterol fumarate inhalation aerosol for long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), according to a statement from AstraZeneca.
She first heard about dimethyl fumarate at an outpatient appointment at the RVI, where her consultant mentioned that the treatment was being tested.
Researchers found that the periodontal biofilm depended for growth on the availability of iron and heme (an iron-containing molecule related to hemoglobin), and that restricting these reduced levels of the enzyme, fumarate reductase.
In March, oral Tecfidera[TM] (dimethyl fumarate, Biogen Idec--formerly "BG-12") joined the ranks of first-line, disease-modifying therapies approved by the U.
Under previous licensing agreements with Gilead, Matrix has obtained nonexclusive rights to produce and market active pharmaceutical ingredients and finished products, including generic versions of Viread (tenofovir disoproxil fumarate, or TDF), Truvada (emtricitabine/tenofovir disoproxil fumarate) and other TDF-based combinations in 95 developing countries.
Fumarate and malate are four carbon intermediates (dicarboxylic acid) in the propionate pathway in which they are reduced to succinate.
One daily intake of Seroquel XR (quetiapine fumarate extended-release tablets) and Seroquel (quetiapine fumarate) has been approved under the European Mutual Recognition Procedure for the stated indications in patients whose manic, mixed or depressive episode has responded to quetiapine treatment, AstraZeneca said in a statement.
Containing ketotifen fumarate as a main ingredient, the product helps alleviate nasal allergy symptoms due to pollen and house-dust mites.