gap junction


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gap junction

n.
An intercellular network of protein channels that facilitates the cell-to-cell passage of ions, hormones, and neurotransmitters.

gap′ junc`tion


n.
Biol. a structure consisting of a series of channels extending across the gap between two cells, allowing the passage of ions, small molecules, etc.
Translations
nexus
References in periodicals archive ?
The Focal adhesion and Gap junction pathways receive and send signals that affect the motility proliferation, differentiation, metabolic transport, apoptosis, and tissue homeostasis of ovarian follicle and mammary gland cells [21].
This study shows how quickly some important cell behaviors are mediated by gap junction communication.
Normal distribution of atrionatriuretic factor (ANF) granules, an intact intercalated disc with clear identification of fully formed fascia adherence and desmosomes with a reconstruction of gap junction (nexus) were also noticed.
It encodes a membrane channel that can dock to identical membrane channels in adjacent cells, to form a "gap junction".
such as gap junctions. Gap junction channels of EE cells are composed of
These phosphoisoforms are believed to reflect the localization of Cx43, patency of the gap junction, and ability to participate in epithelial-stromal communication [51].
Since the correction was not achieved when hAMSCs were cultured separately from CFBE41o- (CFBE) cells, we hypothesised that gap junction (GJ) intercellular communication (GJIC) is likely to have a role in the rescue of basic defects in the CF airway epithelium.
[I.sub.stim] is the stimulus current applied to myocyte membrane, [I.sub.gap] is the current that flows through the gap junction between the myocyte and each fibroblast, n is the total number of fibroblasts, and [G.sub.gap] represents the gap junction conductance.
According to previous studies, it is well known that the two kinds of vascular endothelial cell-cell junction, TJs and AJs, play key roles in the barrier function of BBB [2, 11]; nevertheless, very recently, researchers discovered a third category, gap junction (GC) channels, and the cross work with other cell-cell junctions in maintaining the barrier function [12].
Regulation of gap junction channels by infectious agents and inflammation in the CNS.
An example of the concept is ES1: Here the main question is whether a new AOP for developmental toxicity can be defined on the basis of gap junction changes induced by toxicants, and whether such a key event (KE) would be beneficial for a KE-based test battery.
However, with their topography and discovery being lumped with the gap junction field (i.e., connexin), they were thought for a long time to be more similar to connexin-based proteins.