An example of the concept is ES1: Here the main question is whether a new AOP for developmental toxicity can be defined on the basis of gap junction
changes induced by toxicants, and whether such a key event (KE) would be beneficial for a KE-based test battery.
However, with their topography and discovery being lumped with the gap junction
Background: X-linked Charcot-Marie-Tooth type 1 (CMT1X) disease is one of the most common forms of inherited neuropathy caused by mutations in the gap junction
beta-1 protein (GJB1) gene (also known as connexin 32).
2004) Potent block of Cx36 and Cx50 gap junction
channels by mefloquine.
A somatic mutation in the GJB2 gene, which encodes the gap junction
protein connexin 26, has recently been implicated in the pathogenesis of PEODDN.
Researchers in the neurosciences share their techniques, protocols, and thoughts/reviews on various approaches they use to study gap junction
channels and hemichannels.
We recently found that connexin 30 (Cx30), an astroglial gap junction
subunit expressed postnatally, tunes synaptic activity via an unprecedented non-channel function setting the proximity of glial processes to synaptic clefts, essential for synaptic glutamate clearance efficacy.
12-25 The hexameric Cx43 protein complex connexon, both as a gap junction
and as a hemichannel, forms large-conductance ion channel with chemical gating similar to the Bcl-2 channels.
7-9) In the nervous system, silencing the Cx43 gene down-regulates the inflammatory response, (10) while a gap junction
blocker (heptanol) inhibits the production of TNF-[alpha] in RA synovial tissue.
Another important factor that affects electrical coupling of myocytes is gap junction
function, and oxidative stress impairs gap junction
conduction [30, 53, 54].
If the expanded cumulus cells will lead to decreased gap junction
number, then the course of meiosis inhibition is reduced.
5 as well as the gap junction
protein connexin 43 suggests uniform cardiomyocyte (CMs) development independent of tissue location.