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Related to gelsolin: Profilin


A calcium-regulated actin-binding protein that breaks cytoskeletal actin filaments into smaller pieces, thus transforming the actin network (or gel) into a colloidal solution and influencing cell morphology, motility, and apoptosis.

[gel + sol (since it works upon actin to transform cytoplasm from a gel to a sol) + -in.]
References in periodicals archive ?
Plasma gelsolin and circulating actin correlate with hemodialysis mortality.
Other identified spots included gelsolin, vimentin, gamma enolase, ATP synthase and cytoskeletal protein.
Clic1 plays a role in mouse hepatocarcinoma via modulating Annexin A7 and Gelsolin in vitro and in vivo," Biomedicine and Pharmacotherapy, vol.
The purpose of the present study was to evaluate caspase-3 and gelsolin levels in cerebrospinal fluid (CSF) and plasma associated with secondary damage after SCI, and to evaluate the effects of methylprednisolone and sildenafil on caspase-3 and gelsolin levels as markers of neuroprotection after SCI.
Gelsolin down-regulates lipopolysaccharide-inducedintraamniotic tumor necrosis factor-a production in the midtrimester of pregnancy.
Loss of overall cell shape is probably due to the cleavage of cytoskeletal proteins such as fodrin and gelsolin (Kothakota, 1997) and finally the plasma membrane blebbing seems to be caused by the cleavage of PAK2, a member of the p21-activated kinases family (Rudel and Bokoch, 1997).
We have identified [beta]-actin, tropomyosin, gelsolin and myosin (non-muscle) as the binding partners of MT-3.
Caspase-3 action occurs downstream in the apoptotic pathway and involves in cleaving important substrates such as gelsolin, fodrin, actin, and poly ADP-ribose (Todor et al.
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.
MA), cleaved caspase-3 (Cell Signaling, Beverly, MA), gelsolin (BD Transduction Labs, Lexington, KY), and PKC-[delta] (Santa Cruz Biotechnology, Santa Cruz, CA) was conducted using appropriate primary and secondary antibodies (Pierce Biotechnology, Rockford, IL).
Cytoskeleton and membrane proteins, cellular organisers 1A11 4e-38 NP 990573 Low density lipoprotein Chicken 1B5 2e-49 CAF21863 Gelsolin Sponge 1D7 1e-108 U30467 Alpha-tubulin Spoon worm 1H7 3e-45 CAD91425 Actin related protein Oyster 2G1 2e-15 CAG07401 Low density lipoprotein * Pufferfish 15D9 2e-82 AY026071 Beta-tubulin Choanoflagellate 15D10 2e-43 AF510206 Beta-tubulin Ciliate AV.