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A nucleoside analog, C9H11F2N3O4, used in its hydrochloride form in the treatment of pancreatic cancer and in combination with other drugs to treat breast, ovarian, and non-small cell lung cancer.

[gem-, perhaps shortening and alteration of CCRF-CEM, designation of the leukemia cell culture on which it was first tested + -citabine, nucleoside analog antiviral and anticancer drug suffix; see zalcitabine.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
The growth-inhibitory effects of gemcitabine for PANC-1 and MIA-PaCa2 were determined.
When researchers at King's College Hospital and Southampton University combined the American chokeberry (above) with gemcitabine, a chemotherapy drug used for pancreatic cancer, they discovered it increased the effectiveness of the chemotherapy.
This study reports the use of intravesical gemcitabine in managing patients with high-risk bladder cancer, refractory to Bacillus Calmette-Guerin (BCG).
The results were compared with gemcitabine 160mg/kg, 7-day intervals, intraperitoneal treated mice, as a reference drug [25, 26] in this experiment.
This study has enrolled 200 patients with metastatic pancreatic cancer who were not considered suitable for combination chemotherapy and is designed to evaluate the efficacy and safety of Acelarin monotherapy compared to gemcitabine, with further exploration of patient sub-groups that may derive additional benefit from Acelarin.
Radiation and the chemotherapy drug gemcitabine, which are the standard treatment for pancreatic cancer, both work by causing damage to DNA.
In the human clinical trial, they evaluated the safety and potential efficacy of IVC combined with radiation treatment and gemcitabine chemotherapy for patients with locally advanced pancreatic cancer compared to matched historical controls who received gemcitabine and radiation but not IVC.
These new preclinical results show synergistic antitumour effects in vivo using CAN04, also in combination with carboplatin or oxaliplatin, as well as CAN04 combined with the cisplatin and gemcitabine doublet.
Gemcitabine is a deoxycytidine analog that exhibits anticancer activity against various solid tumors such as pancreatic cancer, lung cancer and prostate cancer (28,29).