gene amplification


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gene amplification

n.
A cellular process characterized by the production of multiple copies of a particular gene or genes to amplify the phenotype that the gene confers on the cell. Drug resistance in cancer cells is linked to amplification of the gene that prevents absorption of the chemotherapeutic agent by the cell.

gene′ amplifica`tion


n.
1. an increase in the frequency of replication of a DNA segment.
2. such an increase induced by a polymerase chain reaction.
[1970–75]
Translations
amplification de gèneamplification génique
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References in periodicals archive ?
Tenders are invited for purchase of advance analytical real time quantitative gene amplification system
Gene amplification is a mechanism responsible for the overexpression of oncogenes.
Polymerase Chain Reaction for phytase gene amplification using 3 sets of primers at 47AdegC annealing temperature and 3mM MgCl2 concentration: Polymerase chain reaction for phytase gene amplification using three sets of primers.
In the overall study group, the rates of HER-2/neu overexpression (score 3+) and gene amplification were 22.3% and 25%, respectively.
FISH on the other hand has an excellent sensitivity and specificity in detecting HER2 gene amplification. One of the major limitations for FISH evaluation of HER2 is its relative high cost and requirement of special instruments.
Loop-mediated Isothermal Amplification Market: Drivers and Restraints The factors responsible for the growth of global loop mediated isothermal amplification market is the increasing prevalence of infectious diseases, growing demand for improved throughput in gene amplification. However, the restricted availability of reagents and instruments, no multiplex capability and limitations related with primer design hinders the growth of the global loop mediated isothermal amplification market.
Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.
For bsh gene amplification, genomic DNA was used as a template and primer for PCR amplification were Lp 1F (5'- CGCTACCGGAATTCATGT GTACTGCCATA-3') and Lp975R (5'-CGCTACCCAAGCTTT TAGTTAACTGCATA-3') (13).
Relationship between the rs1800795 single nucleotide polymorphisms and neuroblastoma risk and MYCN gene amplification status
Biocept's CTC-based assay detected estrogen receptor expression and HER2 gene amplification, which enabled the patient to qualify for anti-HER2 therapy that extended her survival and improved her quality of life.
Deregulation of c-Myc gene expression in tumors and tumor cell lines have been identified by gene amplification, translocation, mutation and higher level of c-Myc RNA.