gene conversion


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.

gene conversion

n.
1. The unequal segregation of alleles to gametes during meiosis, resulting in gametes containing one allele being more numerous than gametes containing the other allele for certain genes.
2. The replacement of one part of a chromosome with a copy of the homologous part on the sister chromosome, often as a consequence of DNA repair.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Mentioned in ?
References in periodicals archive ?
The possible mechanism of the sequence recombination and high variation rate is due to possible gene conversion or transfer where the other four paralogue genes act as donors.
These have been achieved by the antibodies' gene recombination and gene conversion. In conclusion, the efficacy of the hens' immune system has been proven in its elaborate defenses against aggressors by different mechanisms.
Reconstructing the evolutionary history of NOTCH2NL genes revealed that a process called gene conversion was likely responsible for repairing a non-functional version of NOTCH2NL, which originally emerged as a partial duplication of an essential neurodevelopmental gene known as NOTCH2.
Herein, we present the cases of two siblings with different phenotypes and different chromosomal sex who both have a large gene conversion and a point mutation.
All above mentioned genera are widely used in the experimental class of genetics to study crossing over and gene conversion due to the unique arrangement of ascospores in an ascus as genetic model organisms (Ines et al., 2010).
Unidirectional exchange of DNA between two allele of a gene results in gene conversion. Combinatorial variation results when allels undergo constant changes as a result of recombination.
Fujii-Kuriyama, "Evidence for frequent gene conversion in the steroid 21-hydroxylase P-450(C21) gene: implications for steroid 21-hydroxylase deficiency," American Journal of Human Genetics, vol.
Under the name of Hb Lepore, a small group of structurally abnormal Hbs that result from in-frame fusion between the 5' end of the [delta\-globin gene and the 3' end of the [beta]-globin gene is defined, formed by unequal crossover or gene conversion events during meiosis.
Evidence for biased gene conversion in concerted evolution of ribosomal DNA, Science, 1991; 251: 308-310.
The event would be similar to the homologous recombination mechanism during meiosis and the same as gene conversion, involving just a few hundred bp of the heteroduplex during the repair.
Biologists and other scientists from the US, Europe, and Japan examine the proteins involved in recombinational repair and the pathways in which they are employed, such as gene conversion and break-induced replication; how these proteins and pathways are regulated to avoid genomic instability; and how they are coordinated with other nuclear processes, such as transcription and DNA replication.
The work from the laboratory of Michael Lynch, professor of biology at Indiana University, Bloomington, instead indicates that most deleterious DNA sequences contributing to the extinction process actually are present in the sexual ancestors, albeit in recessive form, and simply become exposed via fast-paced gene conversion and deletion processes that eliminate the fit genes from one of the parental chromosomes.