United Kingdom-based AstraZeneca and United States-based MSD have revealed positive results from the Phase III PROfound trial of Lynparza (olaparib) in men with metastatic castration-resistant prostate cancer who have a homologous recombination repair gene mutation
and have progressed on prior treatment with new hormonal anticancer treatments, it was reported yesterday.
AstraZeneca (AZN) and Merck (MRK) announced results from the Phase 3 PROfound trial of Lynparza in men with metastatic castration-resistant prostate cancer - mCRPC - who have an homologous recombination repair gene mutation
and have progressed on prior treatment with new hormonal anticancer treatments.
The medicine is for those newly-diagnosed with ovarian cancer that has spread, who have the BRCA gene mutation
. Inherited BRCA gene mutations
are responsible for about one in five ovarian cancers.
In 1996, two gene mutation
of HFE were found to be responsible for hemochromatosis i.e.
Most cancers develop after a gene mutation
happens during a person's lifetime, in an organ where a cancer later develops.
The same SETX gene mutation
, c.5268delT (p.Phe1756LeufsX30), in heterozygous status was detected in the second case (figure 2).
During her degree she lost her mum to ovarian cancer and later discovered it was the result of her carrying a harmful BRCA2 gene mutation
The origin of the Linear-No-Threshold (LNT) belief was borne in the judgment and passion of Hermann Muller, who was the first to claim that X-rays induced gene mutations
. Muller had indeed made a momentous breakthrough in late 1926 when he found a way to produce quickly copious transgenerational phenotypic changes (e.g., alterations in size, color, or shape) in fruit flies, which he interpreted as being the result of gene mutation
The team also found that in a subset of triple negative breast cancer cells associated with the BRCA1 gene mutation
, LYN could be switched on and increase cancer cell survival directly as a result of the loss of BRCA1.
I was part of a team at Oregon Health & Science University that used CRISPR gene editing to correct a disease-causing gene mutation
in human embryos.
[USA], Oct 10 (ANI): Turns out, people with the natural gene mutation
appear to have an advantage when it comes to diet.