A University of Arizona Cancer Center research team is engaged in a series of studies to investigate how genistein
, a component of soy foods, might suppress the development of breast cancer.
Neonatal rodents exposed to genistein
show alterations in their estrous cycle, behavior, ovarian function, and reproductive tract (reviewed by Jefferson et al.
Soybean ISFs are mainly including daidzein, genistein
, and glycitein (Thomas, 1997).
The effects of exogenous genistein
(GNT) on flavonoid content and antioxidase activity in Ginkgo biloba leaves were investigated.
The major isoflavones include genistin, daidzin, glycitin, equol, and biochanin A and, in particular, genistein
is the most widely investigated isoflavon [Figure 1].
Another tomato produced the same amount of genistein
- a soy bean compound - as 5lb of tofu.
On the contrary, genistein
(GEN) as a phytoestrogen is known to have chemopreventive effects in diverse cancers.
is one of the two primary isoflavones which increases concentrations of TGF-beta that may inhibit the growth of cancer cells.
Other skin-protecting nutrients include: selenium (Brazil nuts), zinc (sesame and pumpkin seeds), green tea polyphenols, proanthocyanidins and resveratrol (grapes), Silymarin (artichokes), genistein
(soy), and curcumin (turmeric).
, daidzein and glycitein are major isoflavones in soy products that comprise, respectively, 50, 40 and 10% of the total soybean isoflavone profile (7).
In an article published May 28, 2014, in the American Journal of Clinical Nutrition, researchers at Northwestern University report the outcome of experiments conducted by their group and others that shows a protective effect for the soy isoflavone genistein
against prostate cancer cell detachment, invasion, and metastasis.
The drugs trial aims to find out whether high doses of the treatment Genistein
Aglycone is effective in people with Sanfilippo disease.