genotoxic

Related to genotoxic: genotoxic carcinogen

ge·no·tox·in

(jē′nə-tŏk′sĭn)

A chemical or other agent that damages cellular DNA, resulting in mutations or cancer.

[New Latin geno-, gene (from Greek genos, race, offspring; see genə- in Indo-European roots) + toxin.]

ge′no·tox′ic adj.

ge′no·tox·ic′i·ty (-sĭs′ĭ-tē) n.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

genotoxic

(ˌdʒɛnəʊˈtɒksɪk)

adj

(Genetics) harmful to genetic material

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

Translations

ge·no·tox·ic

a. genotóxico-a, rel. a una sustancia tóxica nociva al material genético de las células.

English-Spanish Medical Dictionary © Farlex 2012

References in periodicals archive ?

It is important to emphasize that these three urban streams had not been previously analyzed for genotoxic, mutagenic, or cytotoxic potentials.

Water quality of urban streams: the Allium cepa seeds/seedlings test as a tool for surface water monitoring

Concern about the potential mutagenic and carcinogenic effects of genotoxic agents in populations exposed to MMA occupationally has grown, partially due to the possibility that mutagenic effects may occur only after multiple years of exposure, increasing the incidence of cancer and characterizing so-called cumulative effects.

Assessment of methyl methacrylate genotoxicity by the micronucleus test

PAH become genotoxic after their metabolic activation by the enzymes of cytochrome P450 family.

MoBiTec GmbH, Germany, Closes Distribution Agreement with VIDIA Ltd., Czech Republic, to Distribute ELISA Kits for Human Medicine and for Environmental Monitoring

The drug is a genotoxic substance, which means it can affect the DNA of cells and result in toxicity that can possibly lead to cancer.

Drug- tainted Indian shrimps raise stink in US

CloA inhibited DMH induced genotoxic damage in mucosa cells of the distal colon compared with Cont as investigated by single-cell microgel electrophoresis assay.

Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats

Although the cause associated with this increase is not known, in utero and maternal exposure to genotoxic compounds from diet and the environment may be a risk factor for the development of cancer during childhood.

Micronucleus frequencies in umbilical blood

Pulp mill effluents are characterized by their high concentrations of biochemical oxygen demand (up to 13.3g [BOD.sub.5]L), chemical oxygen demand (up to 39.8g COD/L) and suspended solids (up to 6.1g SS/L) (Bajpai, 2000) and their genotoxic effect on aquatic organisms (Salem et al., 1995; Gravato and Santos, 2002; Maria et al., 2003; Fernandez et al., 2007).

Genotoxic effects of kraft pulp mill effluents treated by biological aerobic systems/Efectos genotoxicos de efluentes provenientes de celulosa kraft tratados por sistemas biologicos aerobicos/Efeito genotoxico de efluentes a partir de celulose kraft tratados por sistemas biologicos aerobicos

They present the core concepts, skills, and methods to perform risk assessments, including the fundamentals of cancer biology, chemical carcinogenesis, hormesis, and experimental evidence of thresholds for genotoxic carcinogens; guidelines and regulations for in vitro and in vivo testing; and evaluation of toxicological data and its relevance to hazard evaluation and cancer risk estimation.

Cancer risk assessment; chemical carcinogenesis, hazard evaluation, and risk quantification

* And it has released advice on a guideline on the limits of genotoxic impurities--http://www.ema.europa.eu/docs/ en_GB/document_library/Scientific_guideline/2009/09/WC500002907.pdf

EMA--pharmaceutical industry news in briefs

There are few agricultural studies examining the effects of thiocyclam [17,18], and few studies of its genotoxic effect in literature [19,20].

Cytotoxicity and genotoxicity Potential of thiocyclam in root-tip cells of Allium cepa

Since the Viracept case, however, genotoxic impurities are now more in the focus of the authorities.

The new health believes in having skin in the game: genotoxic impurities, leachables and extractables the tip of the iceberg? Genotoxic impurities, in particular, are at the focus of attention of the regulatory authorities. Low limits of detection in the trace range presuppose the existence of special analytical techniques for detecting these substances

The agency concluded that steviol glycosides are not carcinogenic, genotoxic or associated with any reproductive/developmental toxicity.