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Related to genotoxin: genotoxic carcinogen


A chemical or other agent that damages cellular DNA, resulting in mutations or cancer.

[New Latin geno-, gene (from Greek genos, race, offspring; see genə- in Indo-European roots) + toxin.]

ge′no·tox′ic adj.
ge′no·tox·ic′i·ty (-sĭs′ĭ-tē) n.
References in periodicals archive ?
coli producing cyclomodulin and genotoxin in colon cancer.
In this context, recent advances in the development of techniques and diagnostic tools have certainly enhanced the understanding of how an organism interacts with its environment at individual, cellular and molecular level, and substantial progress has been made to assess the genotoxin induced genetic damage in the aquatic biota [3].
TNT is a haemotoxin, a genotoxin and carcinogen and I know of women who worked in munitions in World War Two who suffered serious anaemia conditions of the bone marrow as a result.
2) There are several mechanistic classes of genotoxin and to guard against genotoxic compounds being developed into drugs, it is a regulatory requirement that all pharmaceutical compounds undergo preclinical genotoxic safety testing.
6,7,8,9,10) This method is increasingly being used in molecular epidemiological studies to investigate the impact of nutrition, lifestyle factors, genotoxin exposure and genotype on DNA damage and cell death.
There are two ways estrogen can induce cancers to form: as a genotoxin and a mitogen.
The Food and Drug Administration (FDA) characterizes the chemical as a potential human carcinogen and genotoxin (meaning it can damage DNA), as well as a known neurotoxha.
Labsystems Oy, of Thermo BioAnalysis, signed an exclusive licensing agreement to manufacture and market Vitotox, a high-speed, high- throughput, low-cost toxicity test that tests drugs for genotoxicity, which damages DNA, by using a genetically modified microorganism that emits light when exposed to a genotoxin.
Bacterial genotoxin triggers FEN1-dependent RhoA activation, cytoskeleton remodeling and cell survival," Journal of Cell Science, vol.
A biosensor for environmental genotoxin screening based on an SOS lux assay in recombinant Escherichia co/icells.
A second OHSU project will study the effects of a potent genotoxin present in the seed of the cycad, a tropical palm-like plant.