This assay is used for the estimation of genotoxin
exposure and Post hazardous exposure effects (23).
impetiginosus alone neither acted as a genotoxin
nor exerted any antigenotoxic effects on spontaneous DNA lesions.
coli Producing Cyclomodulin and Genotoxin
in Colon Cancer," PLoS ONE, vol.
Burgos-Barragan et al., "Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin
and Metabolic Carcinogen," Molecular Cell, vol.
Reproductive consequences of paternal genotoxin
exposure in marine invertebrates.
[146.] Devaux A, Fiat L, Gillet C, Bony S (2011) Reproduction impairment following paternal genotoxin
exposure in brown trout (Salmo trutta) and Arctic charr (Salvelinus alpinus).
TNT is a haemotoxin, a genotoxin
and carcinogen and I know of women who worked in munitions in World War Two who suffered serious anaemia conditions of the bone marrow as a result.
In 2007, Aubrecht reported: "Based on our experience, the overall attrition rate of drug candidates because of genetic safety concerns includes around 12% of drug candidates." (2) There are several mechanistic classes of genotoxin
and to guard against genotoxic compounds being developed into drugs, it is a regulatory requirement that all pharmaceutical compounds undergo preclinical genotoxic safety testing.
(6,7,8,9,10) This method is increasingly being used in molecular epidemiological studies to investigate the impact of nutrition, lifestyle factors, genotoxin
exposure and genotype on DNA damage and cell death.
Estrogen is a mitogen and a genotoxin
. (21-23) An abortion in the first or second trimester leaves the mother with an increased number of Type 1 and 2 lobules.
There are two ways estrogen can induce cancers to form: as a genotoxin
and a mitogen.
The Food and Drug Administration (FDA) characterizes the chemical as a potential human carcinogen and genotoxin
(meaning it can damage DNA), as well as a known neurotoxha.