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Related to genotoxin: genotoxic carcinogen


A chemical or other agent that damages cellular DNA, resulting in mutations or cancer.

[New Latin geno-, gene (from Greek genos, race, offspring; see genə- in Indo-European roots) + toxin.]

ge′no·tox′ic adj.
ge′no·tox·ic′i·ty (-sĭs′ĭ-tē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
coli Producing Cyclomodulin and Genotoxin in Colon Cancer," PLoS ONE, vol.
Burgos-Barragan et al., "Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen," Molecular Cell, vol.
[146.] Devaux A, Fiat L, Gillet C, Bony S (2011) Reproduction impairment following paternal genotoxin exposure in brown trout (Salmo trutta) and Arctic charr (Salvelinus alpinus).
TNT is a haemotoxin, a genotoxin and carcinogen and I know of women who worked in munitions in World War Two who suffered serious anaemia conditions of the bone marrow as a result.
In 2007, Aubrecht reported: "Based on our experience, the overall attrition rate of drug candidates because of genetic safety concerns includes around 12% of drug candidates." (2) There are several mechanistic classes of genotoxin and to guard against genotoxic compounds being developed into drugs, it is a regulatory requirement that all pharmaceutical compounds undergo preclinical genotoxic safety testing.
(6,7,8,9,10) This method is increasingly being used in molecular epidemiological studies to investigate the impact of nutrition, lifestyle factors, genotoxin exposure and genotype on DNA damage and cell death.
Estrogen is a mitogen and a genotoxin. (21-23) An abortion in the first or second trimester leaves the mother with an increased number of Type 1 and 2 lobules.
There are two ways estrogen can induce cancers to form: as a genotoxin and a mitogen.
The Food and Drug Administration (FDA) characterizes the chemical as a potential human carcinogen and genotoxin (meaning it can damage DNA), as well as a known neurotoxha.