There is so far not really an example where it would make sense to work on the human germ line
Therefore, we extracted condition medium from adult mouse Sustentacular cells at different time intervals to evaluate its effect on the induction of BMMSCs to express male germ cell markers and differentiate into male germ line
Testing the Mitochondrial genome, which is transmitted exclusively through the female germ line
, makes it possible to identify relatives," Rabbi Yosef Carmel, the Rabbinical Dean of the Eretz Hemdah Institute for Advanced Jewish Studies, told the Israeli newspaper Makor Rishon.
Loss of MLH1 expression can occur due to either germ line
mutation of the MLH1 gene, as seen for Lynch syndrome, or epigenetic inactivation of the MLH1 gene promoter by hypermethylation, which results in MSI and is seen in approximately 12% of sporadic CRCs.
Thompson S, Clarke AR, Pow AM, Hooper ML, Melton DW Germ line
transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells.
The genomic landscape of localised prostate cancer has been well defined, describing putative pathogenic BRCA2 germ line
mutations as well as somatic and germ line
DNA repair alterations found such as BRCA1, CDK12, FANCA, and RAD51B.
These genes also tend to be active in the germ line
(eggs and sperm and the cells that give rise to them).
Not only does germ line
gene therapy not require the manipulation of normal embryos; it may not even demand the manipulation of abnormal embryos.
ABSTRACT The vasa orthologs have been used as a specific germ line
molecular marker in many animal species.
It is shown that the DNA injected into the cytoplasm of fertilized zebra fish eggs could integrate into the fish genome and be inherited in the germ line
The progenitor cells developed are likely capable of differentiating into other cell types of the intermediate mesodermal lineage as well, most notably the germ line
to generate eggs and sperm in a dish.
However, the role of the X chromosome in these critical stages of germ line
development remains poorly understood.