Walsh et al., "Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline
mismatch repair gene mutation testing," Journal of Clinical Oncology, vol.
mutations have been identified in more than 15 well-characterized genes, such as VHL, SDHB, SDHD, NF1, and RET .
The panel concluded that "heritable germline
genome editing trials must be approached with caution, but caution does not mean that they must be prohibited." Germline
refers to genetic material being passed from generation to generation through the sperm and egg.
Also for Lynparza tablets, the FDA approved a new use (two tablets twice daily instead of eight capsules twice a day) and a new indication (women with deleterious or suspected deleterious germline
BRCA-mutated advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy).
Olaparib monotherapy may be considered in women with ABC harboring a germline
BRCA mutation in early lines of therapy.
The process is termed 'germline
engineering' because any genetically modified child would then pass the changes on to subsequent generations via their own germ cells--the egg and sperm."
In the (http://www.nap.edu/catalog/21913/international-summit-on-human-gene-editing-a-global-discussion) International Summit on Human Gene Editing held in 2015 in Washington D.C., scientists debated the safety risks and ethical hazards of modifying the human embryos and human "germline
" (the genetic blueprint that will be passed on to future generations) using CRISPR.
A small proportion of ovarian cancers are attributable to genetic mutations, with approximately 10%-15% of cases caused by germline
mutations of BRCAl and BRCA2.
The key word here is "intended." Participants know that treating the presenting patient (somatic) often has implications (germline
) for any children that they might have.
One goal of the research is to cure the disease of premature ovarian failure using female germline
stem cells, said senior author Ji Wu.
In the study, the researchers isolated and characterized female germline
stem cells from a single transgenic mouse with cells that fluoresce when activated by a laser.
AstraZeneca achieved positive results from its Phase III OlympiAD trial comparing LYNPARZA (olaparib) tablets (300mg twice daily) to standard of care chemotherapy in the treatment of patients with HER2-negative metastatic breast cancer harboring germline
BRCA1 or BRCA2 mutations.