Reported positive Phase 3 results from SAKURA 1 and SAKURA 2 pivotal trials of RT002 for the treatment of
glabellar (frown) lines, which met all primary and secondary endpoints, and achieved 6-month duration in multiple secondary measurements.
M2 PHARMA-February 21, 2018-Evolus Presents Comparative Data from Phase III Trial of 900 kDa Botulinum Toxin Type A Complexes in
Glabellar Lines at AAD Meeting
ALPHAEON's lead product candidate is DWP-450, a Botulinum toxin Type A for the treatment of
glabellar lines.
Exhibits brisk response to light
glabellar tap or loud noise while sleeping.
double dagger]) EPS includes bradykinesia, cogwheel rigidity, drooling, dystonia, extrapyramidal disorder,
glabellar reflex abnormal, hypokinesia, muscle rigidity, oculogyric crisis, oromandibular dystonia, parkinsonism, psychomotor retardation, tongue spasm, torticollis, tremor, and trismus.
Patients with upper eyelid defects and excision of the medial canthal area underwent reconstruction by tarsal rotational flap and
glabellar rotation flap recruited from the forehead.
It's most likely with
glabellar or periorbital injections but possible with any facial injection.
GlobalData's clinical trial report, "
Glabellar Rhytides Global Clinical Trials Review, H1, 2016" provides an overview of
Glabellar Rhytides clinical trials scenario.
After the induction, and every five minutes during operation, MAP, HR, respiratory rate, RSS (Ramsey Sedation Scale, 1: Nervous, agitated and/or restless, 2: cooperative, orientated, quiet patient, 3: obeying orders, 4: sleeping, responding immediately to the
glabellar stimulation and high voice, 5: sleeping, responding slowly to the
glabellar stimulation and high voice, 6: no response to any kind of stimulations)8, SPO , end-tidal CO2 levels were recorded.
They occur with aging as forehead and
glabellar lines, nasolabial folds, radial lip lines, marionette lines, and lines in the corners of the mouth.
yangtzeensis Lu, 1975 from the Tremadocian Nantsinkwan Formation of northwestern Hunan, South China, in all aspects of the cephalic morphology including: (1) shape and proportions of the cephalon, which has a maximum width at about onethird cephalic length from the posterior margin; (2) a gently tapering forward to almost parallel-sided glabella with a faint transverse
glabellar furrow situated just anterior to the elongate, suboval
glabellar node; (3) broadly triangular basal lobes connected to each other by the low and narrow transverse band (Fig.
Table 18: Incidence of EPS Compared to Placebo in the Monotherapy Bipolar Depression Study LATUDA 20 to 60 80 to 120 Placebo mg/day mg/day (N=168) (N=164) (N=167) Adverse Event Term (%) (%) (%) All EPS events 5 12 20 All EPS events, excluding 2 5 9 Akathisia/ Restlessness Akathisia 2 8 11 Dystonia * 0 0 2 Parkinsonism ** 2 5 8 Restlessness <1 0 3 Note: Figures rounded to the nearest integer * Dystonia includes adverse event terms: dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus ** Parkinsonism includes adverse event terms: bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder,
glabellar reflex abnormal, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, and tremor
