Fundus examination showed glaucomatous
optic disc cupping of 80% [Figure 1]a and [Figure 1]e.
The retrospective case series included 59 glaucomatous
eyes with cataracts and severe visual field loss.
Since von Graefe defined glaucoma and glaucomatous
optic neuropathy (GON) as a disease in 1857, it was believed to happen due to mechanical force on the ONH by a rise in intraocular pressure (IOP) destroying the neuroretinal tissue and the lamina cribrosa (mechanical theory).
The eyes were categorised into the following 4 groups: Group 1--Pseudoexfoliation syndrome (PXS)--Based on the presence of PXF material over the pupil, lens and angles or anyone these, with normal IOP, normal fields and no optic disc changes; Group 2--Eyes with pseudoexfoliation with normal corrected IOP but with glaucomatous
disc and visual field changes; Group 3--Eyes with pseudoexfoliation with raised IOP but with normal disc and visual field; Group 4--Pseudoexfoliative glaucoma (PXG)--Eyes diagnosed to have glaucoma secondary to pseudoexfoliation with increased IOP with glaucomatous
optic disc changes and field defects.
There is increasing evidence that the risk of glaucomatous
optic neuropathy and intraocular pressure (IOP) levels is influenced by CCT15.
Hence, CCT measurement in glaucoma patients may help to identify those patients who are at higher risk of developing glaucomatous
sequel thus enabling the ophthalmologist to treat the disease more aggressively.
When dorzolamide is used as a monotherapy, the drug significantly decreases IOP in healthy and glaucomatous
dogs (CAWRSE et al.
Some general similarities in optic disc morphology are often observed in glaucomatous
and NAION eyes, such as the expansion of the optic disc cup and reduction of the retinal nerve fiber layer (RNFL) thickness (1).
The authors concluded that neuroophthalmologic diseases and optic disc anomalies could also cause RNFL thinning, and state that the differential diagnosis of glaucomatous
and nonglaucomatous optic neuropathies should not depend only on OCT, but requires both RNFL measurements and disc topography parameters, as well as a thorough ophthalmic examination (see pages 267-273).
The DARC count was significantly greater in patients with progressing glaucomatous
In the present study, niacinamide supplementation prevented the development of glaucomatous
changes in glaucoma-prone mice, apparently by decreasing the deleterious effects of elevated intraocular pressure.
This confirmed CCT as an independent risk factor for glaucomatous