MtDNA point mutations have been detected in brain and other central nervous system tumors, such as the gliomas, astrocytomas, gliomatosis
cerebri, medulloblastomas, menengiomas, schwannomas and neurofibromas (25,26).
Differentiation of HSE in imaging should consider limbic encephalitis, gliomatosis
cerebri, cerebral ischemia, cerebral edema after seizure episodes, and MELAS syndrome (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes), among others.
Mesial temporal sclerosis, gliomatosis
cerebri, and MELAS should be included in differential diagnosis, when bilateral temporal lobe involvement is detected on MRI scan .
One patient enrolled in the study had to be excluded after the baseline examination due to treatment for meningeal gliomatosis
A rare form of tumor spread can be associated with GTS known as Gliomatosis
Yue et al., "Inhibitory effect of Jinlong capsules on gliomatosis
cerebri and mechanisms," Pharmaceutical Journal of Chinese People's Liberation Army, vol.
cerebri presenting as intractable epilepsy during early childhood.
Infiltrating low-grade primary brain neoplasm, such as gliomatosis
Clinical and pathological findings in a goat with cerebral gliomatosis
. Vet J 170: 381-383.
Various conditions that are considered in the differential diagnosis include acute cerebral ischemia, infarcts involving top of basilar syndrome, cerebral venous thrombosis, transient cerebral hyperemia, Creutzfeldt-Jakob disease, gliomatosis
cerebri, infectious meningitis, encephalitis, post-infectious encephalomyelitis, vasculitis, epinephrine-induced toxic or metabolic encephalopathy, and demyelinating disorders .
Of the 210 cases 27.6% were germ cell tumours, comprising of 24.76% mature cystic teratomas (2 cases of struma ovarii, 1 strumal carcinoid and 1 squamous cell carcinoma arising in mature cystic teratoma reported), one case of immature teratoma with gliomatosis
peritonei, 4 cases of malignant dysgerminoma and one malignant mixed germ cell tumour (dysgerminoma+yolk sac component).
Nevertheless the ovarian teratomas may be completely asymptomatic up to locally anatomic complications, metastatic aggressive disease or non- metastatic implants as gliomatosis
, or endocrine disturbances as thyrotoxicosis, neuroendocrine tumour behaviour, etc.1-3 The signs and symptoms are the peak of an iceberg and the part under water varies considerably.