In the spinal cord, OvPV in situ hybridization-positive neuronal soma and their projections were dense in the ventral horn in regions of neuronal degeneration and gliosis
(Figure 1, panel C).
Also, histological analysis demonstrated increased expression of neural and myelination markers and decreased reactive gliosis
and inflammation in the brains of animals receiving moderate and high doses of ISC-hpNSC compared to the untreated group.
In chronic lesions, gliosis
and neuronal necrosis can also be found (GRAESSER et al., 2006; LENNOX, 2007, DIAZ-DELGADO et al., 2018).
[4,5] Recently, iron chelators such as VK-28 have been used for decreasing basal as well as iron/ascorbate-induced mitochondrial lipid peroxidation in rats  Serial MRS can be used for the follow-up of PKAN patients on iron chelators to quantitatively assess the axonal damage and gliosis
. The medical treatment of PKAN is ineffective, prolonged, and has many side effects and so surgical modalities like stereo-pallidotomy and thalamotomy,  have also been used to reduce dystonia.
Brain MRI showed small regression of the intrace-rebral abscess and partial gliosis
nine weeks after antibiotic therapy.
We determined density in CT exams (in Hounsfield units, HU) or characteristics of the signal in MRI exams (the dominant signal of the central part of the lesion in T1- and T2- weighted images were taken into consideration - Table II); the presence of calcifications (in CT images); marginal gliosis
in MRI (in FLAIR sequence) and hemosiderin deposits (in T2-weighted images); as well as enhancement after CM administration.
1.30% [+ or -] 0.11%, t = 57.20, P < 0.001) and gliosis
(2.98 [+ or -] 0.24 vs.
MRI revealed an interhemispheric cyst with left frontal lobe gliosis
and cortical dysplasia, as well as aplasia of the rostrum and left genu of the corpus callosum.
Residual cerebellar grey matter within the area of encephalomalacia displayed generalized gliosis
, numerous prominent reactive blood vessels, gitter cell infiltration, spongiosis, and dystrophic mineralization.
At the 6-month follow-up, cranial MRI, hyperintensities suggestive of a cystic encephalomalasic area and surrounding gliosis
, which caused parenchymal loss in the bilateral temporal lobes involving parahippocampal gyri and extending to bilateral insular cortices were observed (Figure 1).