Development of glucosidase
II interface inhibitors; towards a novel class of broad-spectrum antivirals.
Recombinant Enzyme to Replace Alpha Glucosidase
for Pompe Disease - Drug Profile 57
A total of 5 mL [alpha]- glucosidase
enzyme was incubated for 5 min with 1 mL of EEBRB with a series of different concentrations (6.
The antioxidant activity, determined by various assays, and the potential of the polysaccharides to serve as glucosidase
inhibitors also were determined.
Diagnosis is made by estimating the acid alpha glucosidase
activity in either skin biopsy (Fibroblasts), muscle biopsy (Muscle cells) or in white blood cells.
Keywords: Metformin intolerance, type 2 diabetes, sulfonylureas, alpha glucosidase
inhibitors, pioglitazone, SGLT2 inhibitors, DPP4 inhibitors.
The most cost-effective drug is metformin following by economical sulphonylureas and their combination in more severe diabetic patients glucosidase
inhibitors have a limited use as an adjunct drug.
Preliminary study on enzymatic hydrolysis of treated oil palm (Elaeis) empty fruit bunches fibre (EFB) by using combination of cellulase and [beta] 1-4 glucosidase
2010) Discovery, SAR, and biological evaluation of a non-inhibitory chaperone for acid alpha glucosidase
Crude enzyme preparation was analyzed for endoglucanase, - glucosidase
, filter paperase, xylanase and pectinase activity by adopting the methods described elsewhere (Miller, 1959, Sohailet al.
A total of 108 patients were on regimen A that included pioglitazone and subcutaneous human mixture insulin, 117 on B with pioglitazone and sulfonylurea, 87 on C with pioglitazone and metformin, 39 on D with pioglitazone and alpha glucosidase
inhibitors; and 28 on E including pioglitazone monotherapy.
In a further study, linagliptin monotherapy showed superiority in glucose lowering versus placebo and versus voglibose, the most commonly used alpha glucosidase
inhibitor in Japan.