conjugation reactions" that increase water solubility of a drug with a polar moiety glucuronate
, acetate, and sulfate, respectively (11)
Liver accepts and metabolises organophosphates through oxidation and sulfate or glucuronate
conjugation and may undergo oxidative damage in case of organophosphorus poisoning.
Despite the presence of three phenolic hydroxyl groups attached to C-5, C-11, and C-12 on the coumestan skeleton of WEL, a glucuronate
conjugate was preferentially formed (Huang 2015).
Metabolites conjugated with methyl, glucuronate
, and sulfate groups are the predominant forms present in plasma.
3] exists in conjugated forms with sulfate or glucuronate
, with only a small fraction of the total [E.
(with Leucovorin)(Neutrexin, TMTX), U.
The mammalian lignans, enterodiol and enterolactone, can be excreted directly in the feces, or after being absorbed in the gut, they enter the enterohepatic circulation where they are conjugated with glucuronate
, and then excreted in urine and bile [10,11].