Glycemic durability of rosiglitazone, metformin, or glyburide
A comparison of glyburide
and insulin in women with gestational diabetes mellitus, N Engl J Med, 2000 Oct 19;343(16):1134-8.
The 7-year case-control study involved all Ontario residents aged 66 years or older who were admitted to the hospital during 1994-2000 because of drug toxicity and who had been treated in the previous week with glyburide
plus co-trimoxazole, digoxin plus clarithromycin, or an angiotensin-converting enzyme (ACE) inhibitor plus potassium-sparing diuretics.
Jeffrey Glazer, former chief executive officer and chairman, and Jason Malek, former senior vice president of commercial operations, each pled guilty to two felony counts that they conspired to manipulate prices for doxycycline hyclate, a popular antibiotic, and glyburide
, a diabetes medicine.
Repaglinide achieved regression of carotid atherosclerosis (intima-media thickness) in 52% of patients versus 18% for glyburide
(P < 0.01) over 1 year, although levels of HbA1c and CV risk factors were similar for both treatment groups.
On the other hand, there have been "no long-term follow-up studies of infants whose mothers were treated with metformin, glyburide
, or any of the insulin analogs," he noted, and past experience with thalidomide has shown that "what may seem safe in the present may prove to be unsafe in the future."
The fracture rate was 15% on rosiglitazone, 8% on glyburide
, and 7% on metformin (Diab.
More recent evidence suggests that glyburide
and metformin are safe and effective for use in GDM.
The conclusion: Glimepiride, glyburide
, glipizide, and tolbutamide were associated with 33%-43% higher mortality risk than was metformin, Dr.
The state said the probe uncovered evidence of a well-coordinated and long-running conspiracy to fix prices and allocate markets for doxycycline hyclate delayed release, the antibiotic; and glyburide
, the diabetes drug.
, one of the oral anti-hyper-glycemic drugs that we have been able to transfer from use in the nonpregnant diabetic population to use during pregnancy, has been well used and studied by this point in time.
NO This randomized comparison of the two agents found metformin 2.1 times more likely to fail than glyburide
was (95% confidence interval, 1.2-3.9).