heterogeneity by HILI-UPLC of Infinitam (c) and the reference product (a, b, d).
Now, in what may be the first step toward the creation of an effective vaccine against the recalcitrant virus, a team of researchers from the Scripps Research Institute in La Jolla, California, has developed a new technique to analyze the glycan
shield on HIV's protective outer glycoprotein layer.
For a long time structure analysis of the glycan
moieties made only a rather slow progress, due to limitations of the used analytical methods.
With the intention of optimize the glycoproteins synthesis process, which was hindered by the limitations from homogeneous glycans
obtaining, production of the protein backbone, and linkage between glycan
and protein backbone, scientists in Creative Biolabs summarize existing knowledge and technologies to propose enhanced glycoprotein synthesis approaches such as native chemical ligation, bacterial oligosaccharyltransferase, glycoprotein remodeling, and in vivo suppressor tRNA technology.
'By supporting the work of leading researchers like Professor An, Agilent is contributing to advance the fields of glycan
analysis, biopharmaceutical characterization, and quality control,' stated executive sponsor of the award Kevin Killeen, Ph.D., Business Transition Manager for Agilent-ProZyme.
Gagneux and colleagues explained in their study that the uterine cells express a receptor that recognizes a glycan
molecule on the surface of sperm cells.
Transferrin and its glycan
isoform in cerebrospinal fluid (CSF)
Cells of the innate immune system, such as macrophages and dendritic cells express a variety of receptors that bind to sugar (glycan
The study enrolled 47 subjects, who were administered a high-protein diet and randomized to receive either KB195, a comparator glycan
, or negative control, and the dose was escalated during the study.
A research team from the University of Adelaide and Griffith University have been studying the interactions between the toxin and an abnormal glycan
(sugar) expressed on the surface of human cancer cells and released into the blood.
Trainees will have access to leading-edge glycan
research technologies at each of the participating institutions.
(NYSE: A) has closed the acquisition of privately-held glycan
analysis reagents, kits and standards provider ProZyme, Inc., the company said.